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The effect of vitamin K1 supplemention for 12 months on bone mineral density and indices of vitamin K status and bone turnover in adult Crohn s disease patients

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  • Additional Information
    • Contributors:
      HRB
    • Publication Information:
      Cambridge University Press
    • Publication Date:
      2018
    • Collection:
      University of Limerick: Institutional Repository (ULIR)
    • Abstract:
      peer-reviewed ; Adult patients with Crohn’s disease (CD), even those in remission, have been shown to have higher circulating under-g-carboxylated osteocalcin (ucOC) concentrations, a sensitive marker of vitamin K nutritional status(1), compared to age- and sex-matched healthy control subjects(2,3). Increased concentrations of ucOC in CD patients in these studies appear to be positively and negatively associated with the rate of bone turnover(3) and bone mineral density (BMD) at some sites(2), respectively. The aim of our study was to investigate whether supplementation with vitamin K1 (1000 mg/d) for 12 months had a positive effect on the rate of bone turnover and BMD in CD patients. We have previously shown that this level of supplementation maximally suppresses the degree of ucOC in CD patients(4). ; PUBLISHED ; peer-reviewed
    • Relation:
      Proceedings of the Nutrition Society;70 (OCE3), E84; http://dx.doi.org/:10.1017/S0029665111001248; http://hdl.handle.net/10344/6727
    • Accession Number:
      10.1017/S0029665111001248
    • Online Access:
      https://doi.org/10.1017/S0029665111001248
      http://hdl.handle.net/10344/6727
    • Rights:
      Material on these pages is copyright Cambridge University Press or reproduced with permission from other copyright owners. It may be downloaded and printed for personal reference, but not otherwise copied, altered in any way or transmitted to others (unless explicitly stated otherwise) without the written permission of Cambridge University Press. Hypertext links to other Web locations are for the convenience of users and do not constitute any endorsement or authorisation by Cambridge University Press. ; info:eu-repo/semantics/openAccess
    • Accession Number:
      edsbas.BC7D7F58