S1 Text - IonBench: A benchmark of optimisation strategies for mathematical models of ion channel currents

A: Problem definitions. A detailed description of the problems implemented in ionBench, including the protocols, data, parameter sampling methods and simulation settings. B: Model solve time. A comparison of model solve times for different approaches. C: Significance. Pseudocode implementations of the ERT bootstrapping algorithm and further method details and results for testing significance. D: Profile likelihood. Profile likelihood plots for each of the five problems. E: Performance of all approaches. Reproductions of Fig 7 showing the performance of all approach-problem pairings on their best run. (PDF)