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Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac

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  • Additional Information
    • Contributors:
      Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.; Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.; orcid:0000-0002-5600-8162; Yalçın, Murat; Coşkun, Melis Debreli; AAG-6956-2021; AAF-3992-2020; 57192959734; 57193066146
    • Publication Information:
      Dove Medical
    • Publication Date:
      2017
    • Collection:
      Açık Erişim@BUU (Bursa Uludağ Üniversitesi)
    • Abstract:
      NanoPharmaceuticals LLC (Rensselaer, NY, USA) ; The tetraiodothyroacetic acid (tetrac) component of nano-diamino-tetrac (NDAT) is chemically bonded via a linker to a poly(lactic-co-glycolic acid) nanoparticle that can encapsulate anticancer drugs. Tetrac targets the plasma membrane of cancer cells at a receptor on the extracellular domain of integrin alpha v beta 3. In this study, we evaluate the efficiency of NDAT delivery of paclitaxel and doxorubicin to, respectively, pancreatic and breast cancer orthotopic nude mouse xenografts. Intra-tumoral drug concentrations were 5-fold (paclitaxel; P < 0.001) and 2.3-fold (doxorubicin; P < 0.01) higher than with conventional systemic drug administration. Tumor volume reductions reflected enhanced xenograft drug uptake. Cell viability was estimated by bioluminescent signaling in pancreatic tumors and confirmed an increased paclitaxel effect with drug delivery by NDAT. NDAT delivery of chemotherapy increases drug delivery to cancers and increases drug efficacy.
    • File Description:
      application/pdf
    • ISSN:
      1178-2013
    • Relation:
      Makale - Uluslararası Hakemli Dergi; International Journal of Nanomedicine; Yurt dışı; Sudha, T. vd. (2017). ''Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac''. International Journal of Nanomedicine, 12, 1305-1315.; https://doi.org/10.2147/IJN.S123742; https://www.dovepress.com/targeted-delivery-of-paclitaxel-and-doxorubicin-to-cancer-xenografts-v-peer-reviewed-fulltext-article-IJN; http://hdl.handle.net/11452/30051; 000394048400002; 2-s2.0-85013472911; 1305; 1315; 12
    • Accession Number:
      10.2147/IJN.S123742
    • Online Access:
      http://hdl.handle.net/11452/30051
      https://doi.org/10.2147/IJN.S123742
      https://www.dovepress.com/targeted-delivery-of-paclitaxel-and-doxorubicin-to-cancer-xenografts-v-peer-reviewed-fulltext-article-IJN
    • Rights:
      info:eu-repo/semantics/openAccess ; Atıf Gayri Ticari Türetilemez 4.0 Uluslararası ; http://creativecommons.org/licenses/by-nc-nd/4.0/
    • Accession Number:
      edsbas.BF569004