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Low risk of haematomas with intramuscular vaccines in anticoagulated patients: a systematic review with meta-analysis

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  • Additional Information
    • Publication Information:
      Springer Nature
    • Publication Date:
      2022
    • Collection:
      Universidade de Lisboa: repositório.UL
    • Abstract:
      © The Author(s). 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. ; Introduction: The summary of product characteristics of vaccines administered intramuscularly, including the vaccine for coronavirus SARS-CoV-2 (COVID-19) and Influenza, warned for risks of bleeding in patients treated with oral anticoagulants. We aimed to estimate the incidence of major bleeding events in this setting and to compare these risks against other vaccination routes. Methods: This systematic review included all prospective and retrospective studies enrolling anticoagulated patients that received intramuscular vaccination, published until December 2020 in CENTRAL, MEDLINE and EMBASE. The outcomes of interest were major bleeding and haematoma related with vaccination. The incidence of the outcomes was estimated through a random-effects meta-analysis using the Freeman-Turkey transformation. The results are expressed in percentages, with 95%-confidence intervals (95%CI), limited between 0 and 100%. When studies compared intramuscular ...
    • Relation:
      https://thrombosisjournal.biomedcentral.com/; Thromb J. 2022 Feb 16;20(1):9; http://hdl.handle.net/10451/51420
    • Accession Number:
      10.1186/s12959-022-00367-1
    • Online Access:
      http://hdl.handle.net/10451/51420
      https://doi.org/10.1186/s12959-022-00367-1
    • Rights:
      openAccess ; http://creativecommons.org/licenses/by/4.0/
    • Accession Number:
      edsbas.C5824651