Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Infection of the basal ganglia by a murine coronavirus

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Publication Date:
      1985
    • Collection:
      UMB Digital Archive (University of Maryland, Baltimore)
    • Abstract:
      The coronavirus, mouse hepatitis virus strain A59 (MHV-A59), causes mild encephalitis and chronic demyelination. Immunohistochemical techniques showed that MHV-A59-infected C57BL/6 mice contained dense deposits of viral antigen in the subthalamic nucleus and substantia nigra, with fewer signs of infection in other regions of the brain. The animals showed extra- and intracellular vacuolation, neuronal loss, and gliosis in the subthalamic-nigral region. Such localization is unprecedented among known viral encephalitides of humans and other species. This infection by a member of a viral class capable of causing both encephalitis and persistent infection in several species may be related to postencephalitic parkinsonism. ; https://doi.org/10.1126/science.2992088
    • Relation:
      Science; https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022353941&doi=10.1126%2fscience.2992088&partnerID=40&md5=8a99480540b8ffb9c10d6731ab24b65d; http://hdl.handle.net/10713/12438; 2992088; Yes
    • Accession Number:
      10.1126/science.2992088
    • Online Access:
      http://hdl.handle.net/10713/12438
      https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022353941&doi=10.1126%2fscience.2992088&partnerID=40&md5=8a99480540b8ffb9c10d6731ab24b65d
      https://doi.org/10.1126/science.2992088
    • Accession Number:
      edsbas.C6028C83