Neuroprotective Evaluation of Modified Naphthalene Derivative by Cerebral Occlusion Method in Rat

The present study has been carried out using rats for investigation of learning task. The passive avoidance task is a fear-aggravated test used to evaluate learning and memory in rodent models of CNS disorders. This result supports the ideas, which might be due to a decrease in gene transcription, translation and enhance cholinergic activity thereby improving cognitive function. Evaluation of the protective effect on rat brain oxidative stress parameters and antioxidant mechanisms was an important aim of our study. The activity of SOD is a sensitive index in oxidative damage as it scavenges the superoxide anion to form hydrogen peroxide leading to diminish the toxic effects. The catalase is enzymatic antioxidants, widely distributed in all animal tissues that decompose hydrogen peroxide and protect the tissue from highly reactive hydroxyl radicals. Data revealed that administration of Ethanolic extract of MND increased the activity of SOD and CAT as reported during supplementation. Glutathione reduced, glutathione reductase and glutathione-S-transferase is thought to be the fundamental antioxidant enzymes, for they are closely related to the direct elimination of reactive oxygen species. Therefore, the reduction in the activity of these enzymes may result in a number of deleterious effects due to the accumulation of superoxide radicals and hydrogen peroxide, linked with neurodegenerative diseases. Supplementation of Ethanolic extract of MND for seven days improved the activity, showing protection against free radicals. From these results, it was inferred that administration of SA in healthy rat attenuated brain oxidative damages, increased activity of antioxidant enzymes and GSH. Although the mechanisms underlying these effects are still unknown and require more pharmacological, neurochemical and pharmacokinetic research to establish any therapeutic advantage. However, excessive use of Ethanolic extract of MND is could be suggested for the prevention of cognitive decline during aging and neurodegenerative ...