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Prognostic Role of Pre- and Post-Treatment [18F]FDG PET/CT in Squamous Cell Carcinoma of the Oropharynx in Patients Treated with Chemotherapy and Radiotherapy

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  • Additional Information
    • Contributors:
      Dondi, Francesco; Gazzilli, Maria; Albano, Domenico; Rizzo, Alessio; Treglia, Giorgio; Pisani, ANTONIO ROSARIO; Palumbo, Carmen; Rubini, Dino; Racca, Manuela; Rubini, Giuseppe; Bertagna, Francesco
    • Publication Date:
      2024
    • Collection:
      Università degli Studi di Bari Aldo Moro: CINECA IRIS
    • Abstract:
      BACKGROUND: The prognostic role of imaging with [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) in oropharynx cancer (OPC) has been demonstrated in the past. The aim of this study was to assess the prognostic impact of both baseline and post-treatment PET/CT in patients with OPC and treated with chemo- and/or radiotherapy. METHODS: The PET/CT parameters of scans performed before and after therapy were collected and analyzed to find significant prognosticators for progression-free survival (PFS) and overall survival (OS). Human papillomavirus (HPV) infection's influence on the prognosis was also taken into account. RESULTS: A total of 66 patients were included in the study. The staging volumetric parameters of PET/CT were significant prognosticators for OS, while the same parameters were affordable predictors for PFS at the restaging evaluation. No significant correlations between HPV infection and PET/CT parameters were reported. CONCLUSION:.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/39189199; info:eu-repo/semantics/altIdentifier/wos/WOS:001322885600001; volume:12; issue:3; numberofpages:13; journal:MEDICAL SCIENCES; https://hdl.handle.net/11586/500900
    • Accession Number:
      10.3390/medsci12030036
    • Online Access:
      https://hdl.handle.net/11586/500900
      https://doi.org/10.3390/medsci12030036
      https://www.mdpi.com/2076-3271/12/3/36
    • Rights:
      info:eu-repo/semantics/openAccess
    • Accession Number:
      edsbas.D13E3F7E