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The association between blood pressure variability (BPV) with dementia and cognitive function: a systematic review and meta-analysis protocol

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  • Additional Information
    • Publication Information:
      BMC
    • Publication Date:
      2018
    • Collection:
      The University of Adelaide: Digital Library
    • Abstract:
      BACKGROUND:A body of empirical work demonstrates that wide fluctuations in a person's blood pressure across consecutive measures, known as blood pressure variability (BPV), hold prognostic value to predict stroke and transient ischemic attack. However, the magnitude of association between BPV and other neurological outcomes remains less clear. This systematic review aims to pool together data regarding BPV with respect to incident dementia, cognitive impairment, and cognitive function. METHODS:Electronic databases (MEDLINE, EMBASE, and SCOPUS) will be searched for the key words blood pressure variability and outcomes of dementia, cognitive impairment, and cognitive function. Authors and reference lists of included studies will also be contacted to identify additional published and unpublished studies. Eligibility criteria are as follows: population-adult humans (over 18 years but with no upper age limit) without dementia at baseline, with or without elevated blood pressure, or from hypertensive populations (systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg or use of antihypertensive drug for hypertension) and from primary care, community cohort, electronic database registry, or randomized controlled trial (RCT); exposure-any metric of BPV (systolic, diastolic or both) over any duration; comparison-persons without dementia who do not have elevated BPV; and outcome-dementia, cognitive impairment, cognitive function at follow-up from standardized neurological assessment, or cognitive testing. Article screening will be undertaken by two independent reviewers with disagreements resolved through discussion. Data extraction will include original data specified as hazard ratios, odds ratios, correlations, regression coefficients, and original cell data if available. Risk of bias assessment will be undertaken by two independent reviewers. Meta-analytic methods will be used to synthesize the data collected relating to the neurological outcomes with Comprehensive Meta-Analysis Version 2.0 ...
    • File Description:
      application/pdf
    • ISSN:
      2046-4053
    • Relation:
      Systematic Reviews, 2018; 7(1):163-163; http://hdl.handle.net/2440/129066; Tully, P.J. [0000-0003-2807-1313]; Turnbull, D.A. [0000-0002-7116-7073]; Burns, N.R. [0000-0003-3456-6734]; Cosh, S. [0000-0002-8003-3704]; Dorstyn, D. [0000-0002-7799-8177]; Mahajan, R. [0000-0003-3375-5568]; Drioli-Phillips, P. [0000-0001-9074-7391]
    • Accession Number:
      10.1186/s13643-018-0811-9
    • Online Access:
      http://hdl.handle.net/2440/129066
      https://doi.org/10.1186/s13643-018-0811-9
    • Rights:
      © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
    • Accession Number:
      edsbas.D5B80839