Abstract: Vitamin D is relevant to several processes in the body mainly in the intracellular mechanisms affecting parathyroid hormone and calcitonin regulation, regulation of vitamin D production by negative feedback and calcium and phosphorous level regulation. Vitamin D may be synthesised in the dermal layer of the skin or absorbed through the diet and utilised. Its biosynthesis initiates from cholesterol and its derivatives and is followed by a cascade of reactions, completed in the kidneys and transported via the blood to where it is utilized. The vitamin D receptor determines the physiological effects of vitamin D and any mutations will cause imbalances in bone homeostasis. ; peer-reviewed
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