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The form of PEG matters: PEG conjugated with lipids and not PEG alone could be the specific form involved in allergic reactions to COVID‐19 vaccines

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  • Additional Information
    • Publication Information:
      Wiley-Blackwell Publishing, Inc.
    • Publication Date:
      2022
    • Collection:
      University of Zurich (UZH): ZORA (Zurich Open Repository and Archive
    • Abstract:
      The excipient polyethylene glycol (PEG) contained in the mRNA vaccines for COVID-19 has been pointed out as one of the possible triggers of the hypersensitivity reactions that have been described since the beginning of the vaccine campaigns for COVID-19 protection.1 However, PEG is not present in the mRNA vaccines in an isolated form but in conjugation with lipid-nanoparticles (LNPs), which are spherical vesicles constituted by ionizable lipids, thanks to a process called PEGylation, which could potentially alter the immunogenic properties of PEG. PEG coats the surface of the LNPs reducing opsonization, aggregation, and improving mRNA delivery to the target cells.
    • File Description:
      application/pdf
    • ISSN:
      0105-4538
    • Relation:
      https://www.zora.uzh.ch/id/eprint/213042/1/the_specific.pdf; info:pmid/34816455; urn:issn:0105-4538
    • Accession Number:
      10.1111/all.15187
    • Online Access:
      https://www.zora.uzh.ch/id/eprint/213042/
      https://www.zora.uzh.ch/id/eprint/213042/1/the_specific.pdf
      https://doi.org/10.1111/all.15187
    • Rights:
      info:eu-repo/semantics/openAccess
    • Accession Number:
      edsbas.D9FAE4CC