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Detection of enteroviruses in stools precedes islet autoimmunity by several months : possible evidence for slowly operating mechanisms in virus-induced autoimmunity

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  • Additional Information
    • Contributors:
      Institute for Molecular Medicine Finland; Research Programs Unit; Diabetes and Obesity Research Program; Mikael Knip / Principal Investigator; Clinicum; Lastentautien yksikkö; Children's Hospital; HUS Children and Adolescents
    • Publication Information:
      Springer
    • Publication Date:
      2018
    • Collection:
      Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto
    • Abstract:
      Aims/hypothesis This case-control study was nested in a prospective birth cohort to evaluate whether the presence of enteroviruses in stools was associated with the appearance of islet autoimmunity in the Type 1 Diabetes Prediction and Prevention study in Finland. Methods Altogether, 1673 longitudinal stool samples from 129 case children who turned positive for multiple islet autoantibodies and 3108 stool samples from 282 matched control children were screened for the presence of enterovirus RNA using RT-PCR. Viral genotype was detected by sequencing. Results Case children had more enterovirus infections than control children (0.8 vs 0.6 infections per child). Time-dependent analysis indicated that this excess of infections occurred more than 1 year before the first detection of islet autoantibodies (6.3 vs 2.1 infections per 10 follow-up years). No such difference was seen in infections occurring less than 1 year before islet autoantibody seroconversion or after seroconversion. The most frequent enterovirus types included coxsackievirus A4 (28% of genotyped viruses), coxsackievirus A2 (14%) and coxsackievirus A16 (11%). Conculusion/hypothesis The results suggest that enterovirus infections diagnosed by detecting viral RNA in stools are associated with the development of islet autoimmunity with a time lag of several months. ; Peer reviewed
    • File Description:
      application/pdf
    • Relation:
      This study was funded by the Scientific Foundation of the City of Tampere, Finnish Cultural Foundation, Pirkanmaa Regional fund, Finnish Funding Agency for Technology and Innovation, Competitive Research Funding of the Tampere University Hospital, JDRF, Diabetes Research Foundation, Academy of Finland, Diabetes Research Foundation in Finland, Sigrid Juselius Foundation, Reino Lahtikari Foundation and European Commission (Persistent Virus Infection in Diabetes Network [PEVNET] Frame Programme 7, Contract No. 261441). In addition, it was partly funded by Sanofi Pasteur and Vactech Ltd. The study sponsor was involved in the design of the study and provided editorial assistance when submitting the report for publication.; Honkanen , H , Oikarinen , S , Nurminen , N , Laitinen , O , Huhtala , H , Lehtonen , J , Ruokoranta , T M , Hankaniemi , M M , Lecouturier , V , Almond , J , Tauriainen , S , Simell , O , Ilonen , J , Veijola , R , Viskari , H , Knip , J M & Hyöty , H 2017 , ' Detection of enteroviruses in stools precedes islet autoimmunity by several months : possible evidence for slowly operating mechanisms in virus-induced autoimmunity ' , Diabetologia , vol. 60 , no. 3 , pp. 424-431 . https://doi.org/10.1007/s00125-016-4177-z; http://hdl.handle.net/10138/236407; 2e3aec06-2eb6-4839-8dbc-2849a61115f7; 85008674656; 000394462100008
    • Online Access:
      http://hdl.handle.net/10138/236407
    • Rights:
      info:eu-repo/semantics/openAccess ; openAccess
    • Accession Number:
      edsbas.DC8614D5