Palliative radiotherapy of soft tissue tumoral masses based on diagnostic instead of planning computed tomography scans

Background and purpose: Radiotherapy (RT) treatment planning is based on a planning computed tomography scan (pCT), while the decision to treat is often already established on a diagnostic CT scan (dCT). The objective of this study was to evaluate the usage of dCT for palliative radiation planning of soft tissue tumoral masses (STTMs), removing the need for a pCT scan and associated attendances. Materials and methods: RT planning was performed retrospectively to 38 STTMs of 7 anatomical sites using volumetric modulated arc therapy techniques in dCT and transferred to pCT. The dose of clinical target volumes (CTV), D(95 %,50 %), were compared between the plans. The patient setup was assessed in cone-beam CT scans. Results: The differences of D(95 %,50 %) between dCT and pCT plans were the lowest in the STTMs of the thoracic cage (0.9 %,0.9 %), STTMs in the inguinal area (0.8 %,1.3 %) and in mediastinal masses associated with superior vena cava syndrome (SVCS) (1.1 %,1.3 %), while the differences increased for other sites. The patient setup was acceptable for 88 % of mediastinal masses associated with SVCS and ≤ 60 % of cases in other sites comparing pCT and CBCT images with a strict margin of 6 mm, but all cases fitted to increased 2 cm margin. Conclusions: This study demonstrated the possibility of using dCT scans for palliative RT planning of STTMs for mediastinal masses associated with SVCS and for STTMs in the thoracic cage and in the inguinal area, indicating the potential feasibility of this procedure for clinical use. ; Peer reviewed