Can Ischemia-Modified Albumin Be Used as a Diagnostic Marker in Acute Coronary Syndrome? Research Article ; İskemi-Modifiye Albümin Akut Koroner Sendromda Tanısal Belirteç Olarak Kullanılabilir mi? Araştırma Makalesi

Introduction: Acute coronary syndromes (ACS) are the main cause of mortality and morbidity worldwide. Appropriate management of patients presenting to emergency departments (ED) with suspected ACS depends on early detection of signs of cardiac ischemia. Aim: In this study, we aimed to investigate the diagnostic value of ischemia modified albümin (IMA) in ACS. Metho: The study included 169 patients admitted to the ED between October 2012 and April 2013 with chest pain. Albumin, troponin-T and IMA were measured in the patients. 21 patients were included in the Non–St-Segment Elevation Myocardial İnfarctions (NSTEMI) group and 49 patients were included in the unstable angina pectoris (UAP) group. The control group included 99 patients. At the end of the study, the parameters of the three groups were compared. Results: The IMA level of NSTEMIgroup was higher than the control group (0.33±0.03, 0.24±0.04, p<0.001). Similarly, the IMA level of UAP group was higher than the control (0.29±0.011, 0.24±0.04 p<0.001). IMA and IMA/Albumin levels of the ACS group were also higher than the control group (0.30±0.029, 0.241±0.041 p<0.001). Conclusion: IMA levels were higher in both NSTEMI group and UAP group compared to the control group in the early periods when other myocardial damage markers were negative in patients admitted to the ED with chest pain. This suggests that IMA level may play a more important role than troponin in risk assessment and determination of treatment strategy in patients admitted to the ED with suspected ACS in the early hours. ; Giriş: Akut koroner sendromlar (AKS) Dünya’da mortalite ve morbiditenin ana sebebidir. AKS tedavisi kardiyak iskemi bulgularının erken dönemde belirlenmesine bağlıdır. Klasik kardiyak belirteçlerin erken tanı için klinik kullanımda bazı kısıtlılıkları vardır. Bu nedenle yeni kardiyak belirteçlere ihtiyaç vardır. Amaç: Bu çalışmamızda İskemi modifiye albümin (IMA)’nin Akut Koroner Sendromdaki tanısal değerini araştırmayı amaçladık. Yöntem: Çalışmaya Ekim 2012 ile Nisan ...