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P. gingivalis in Periodontal Disease and Atherosclerosis - Scenes of Action for Antimicrobial Peptides and Complement.

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  • Additional Information
    • Publication Information:
      Frontiers
    • Publication Date:
      2015
    • Collection:
      University of Leicester: Leicester Research Archive (LRA)
    • Abstract:
      According to the NHS, it is estimated that over 50% of the adult population are, to some extent, affected by gum disease and approximately 15% of UK population have been diagnosed with severe periodontitis. Periodontitis, a chronic polymicrobial disease of the gums, causes inflammation in its milder form, whereas in its severe form affects the surrounding tissues and can result in tooth loss. During periodontitis, plaque accumulates and sits between the junctional epithelium and the tooth itself, resulting in inflammation and the formation of a periodontal pocket. An interface is formed directly between the subgingival bacteria and the junctional epithelial cells. Bacterial pathogens commonly associated with periodontal disease are, among others, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, together known as the "red complex." This review will mostly concentrate on the role of P. gingivalis, a Gram-negative anaerobic bacterium and one of the major and most studied contributors of this disease. Because periodontal disease is associated with the development of atherosclerosis, it is important to understand the local immune response to P. gingivalis. Innate immune players, in particular, complement and antimicrobial peptides and their effects with regard to P. gingivalis during periodontitis and in the development of atherosclerosis will be presented. ; Aline Dupont was supported by the DFG priority program SPP 1656 from the German Research Foundation. ; Peer-reviewed ; Publisher Version
    • ISSN:
      1664-3224
    • Relation:
      http://www.ncbi.nlm.nih.gov/pubmed/25713575; Frontiers in Immunology, 2015, 6:45.; http://journal.frontiersin.org/article/10.3389/fimmu.2015.00045/abstract; http://hdl.handle.net/2381/32816
    • Accession Number:
      10.3389/fimmu.2015.00045/abstract
    • Accession Number:
      10.3389/fimmu.2015.00045
    • Online Access:
      http://journal.frontiersin.org/article/10.3389/fimmu.2015.00045/abstract
      http://hdl.handle.net/2381/32816
      https://doi.org/10.3389/fimmu.2015.00045
    • Rights:
      © 2015 Hussain, Stover and Dupont. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
    • Accession Number:
      edsbas.F5F9723B