Abstract: Infection is one of the most common causes that leads to joint prosthesis failure. In the present work, biodegradable sol-gel coatings were investigated as a promising controlled release of antibiotics for the local prevention of infection in joint prostheses. Accordingly, a sol-gel formulation was designed to be tested as a carrier for 8 different individually loaded antimicrobials. Sols were prepared from a mixture of MAPTMS and TMOS silanes, tris(tri-methylsilyl)phosphite, and the corresponding antimicrobial. In order to study the cross-linking and surface of the coatings, a battery of examinations (Fourier-transform infrared spectroscopy, solid-state 29Si-NMR spectroscopy, thermogravimetric analysis, SEM, EDS, AFM, and water contact angle, thickness, and roughness measurements) were conducted on the formulations loaded with Cefoxitin and Linezolid. A formulation loaded with both antibiotics was also explored. Results showed that the coatings had a microscale roughness attributed to the accumulation of antibiotics and organophosphites in the surface protrusions and that the existence of chemical bonds between antibiotics and the siloxane network was not evidenced. ; This research was funded by the Regional Government of Madrid through the program ADITIMAT (ref. P2018/NMT-4411) and CIBERINFEC-CIBER of Infectious Diseases (CB21/13/00043). B.T. would like to thank the Spanish Ministry of Education, Culture, and Sports for the support through FPU grant (FPU17/05977).
Relation: Comunidad de Madrid. P2018/NMT-4411/ADITIMAT; Comunidad de Madrid. CB21/13/00043/CIBERINFEC-CIBER; Gobierno de España. FPU17/05977; Toirac, B., Garcia-Casas, A., Monclús, M. A., Aguilera-Correa, J. J., Esteban, J., & Jiménez-Morales, A. (2022). Influence of addition of antibiotics on chemical and surface properties of sol-gel coatings. Materials, 15(14); http://hdl.handle.net/10016/36936; https://doi.org/10.3390/ma15144752; 14; 20; Materials; 15; AR/0000031409
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