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Synthesis and crystal structure of phosphorylated estrogen receptor ligand binding domain

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  • Additional Information
    • Publication Information:
      Wiley-VCH Verlag
    • Publication Date:
      2010
    • Collection:
      Eindhoven University of Technology (TU/e): Research Portal
    • Abstract:
      Chemical protein synthesis allows the generation of milligram quantities of correctly folded and previously inaccessible tyrosine-phosphorylated estrogen receptor a (ERa) and ß (ERß) ligand binding domains. By using this synthetic strategy, the crystal structure of a post-translationally modified nuclear receptor (pY488 ERß) could be obtained for the first time
    • File Description:
      application/pdf
    • Relation:
      http://repository.tue.nl/712745
    • Online Access:
      http://repository.tue.nl/712745
    • Rights:
      Copyright (c) Möcklinghoff, S Sabine ; Copyright (c) Rose, R ; Copyright (c) Carraz, M Maëlle ; Copyright (c) Visser, A ; Copyright (c) Ottmann, C Christian ; Copyright (c) Brunsveld, L Luc
    • Accession Number:
      edsbas.F689DA71