SPECIFIC ABSORPTION RATE (SAR) AND NEED FOR REDUCED INTERPARTICLE MAGNETIC INTERACTION

Surface modified superparamagneticFe3O4 nanoparticles were prepared by alkaline co-precipitation of water soluble Fe(II) and Fe(III) salts.Fe3O4nanoparticles were surface modified with folic acid (FA) and ascorbic acid (AA).Samples were characterized by X-ray diffractometry, transmission electron microscopy, fourier transform infrared spectroscopy, thermogravimetry, vibrating sample magnetometry and induction heating study. X-ray diffractometry study has shown that the samples crystallize into a single cubic phase with a = b = c = 8.396±0.03 Å.The synthesized nanoparticles have maximum probable average size of 10 – 12 nm. The nanoparticles prepared in presence of ascorbic acid was found to have more uniform particle and size distribution. The sufficiently high magnetization, induction heating abilities, high specific absorption rate (SAR) values and cell viability profiles on HeLa cells opened a scope for further in vivo study for cancer hyperthermia applications. The study observed that particle size and shape, reduced interparticle magnetic interactions and surface modification are necessary for practical applicability