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Calcium ionophore improves embryonic development and pregnancy outcomes in patients with previous developmental problems in ICSI cycles

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  • Additional Information
    • Publication Information:
      BMC, 2022.
    • Publication Date:
      2022
    • Collection:
      LCC:Gynecology and obstetrics
    • Abstract:
      Abstract Background Calcium (Ca2+) ionophores are now mainly considered as efficient treatments for fertilization failure. Recently, its application for rescuing poor embryo development was proposed but still non-routine. This study aimed to explore whether Ca2+ ionophore improves embryo development and pregnancy outcomes in patients with poor embryo development in previous intracytoplasmic sperm injection (ICSI) cycles. Methods This study included 97 patients undergoing assisted oocyte activation (AOA) with Ca2+ ionophore (calcimycin, A23187) treatment. Preimplantation embryonic development and clinical outcomes were compared between ICSI-AOA cycles (AOA group) and previous ICSI cycles of the same patients in which poor embryo developmental potential was present (non-AOA group). Subgroups stratified by maternal age (
    • File Description:
      electronic resource
    • ISSN:
      1471-2393
    • Relation:
      https://doaj.org/toc/1471-2393
    • Accession Number:
      10.1186/s12884-022-05228-3
    • Accession Number:
      edsdoj.24aa302293f64172ac7ca83d476f4742