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The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis

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  • Additional Information
    • Publication Information:
      Nature Portfolio, 2021.
    • Publication Date:
      2021
    • Collection:
      LCC:Science
    • Abstract:
      Genomic amplification of chromosome 3q often encodes proteins that contribute to cancer development. Here the authors identify a non-coding product of the 3q region, the lncRNA PLANE that promotes tumorigenesis through the deregulation of transcriptional corepressor NCOR2 pre-mRNA splicing.
    • File Description:
      electronic resource
    • ISSN:
      2041-1723
    • Relation:
      https://doaj.org/toc/2041-1723
    • Accession Number:
      10.1038/s41467-021-24099-4
    • Accession Number:
      edsdoj.5b9cdaaeb58b43eabf91f4a962656e8e