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Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids

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  • Additional Information
    • Publication Information:
      Nature Portfolio, 2022.
    • Publication Date:
      2022
    • Collection:
      LCC:Biology (General)
    • Abstract:
      Multimodal single-cell analysis on iPSC-derived kidney organoids shows that inhibiting EZH2 attenuates TGFβ1-induced fibrotic gene expression and changes in chromatin accessibility, highlighting a potential therapeutic strategy for renal fibrosis.
    • File Description:
      electronic resource
    • ISSN:
      2399-3642
    • Relation:
      https://doaj.org/toc/2399-3642
    • Accession Number:
      10.1038/s42003-022-04264-1
    • Accession Number:
      edsdoj.7c0970e160e847bc9ea14f1bd75e80a3