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Engineered phenylalanine hydroxylase coupled with an effective cofactor synthesis and regeneration system for high-yield production of 5-hydroxytryptophan

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  • Additional Information
    • Publication Information:
      SpringerOpen, 2025.
    • Publication Date:
      2025
    • Collection:
      LCC:Technology
      LCC:Chemical technology
      LCC:Biotechnology
    • Abstract:
      Abstract 5-Hydroxytryptophan (5-HTP) is widely used as a natural remedy for sleep disorders. In terms of biosafety, bio-derived 5-HTP is preferred over chemically synthesized 5-HTP. However, the low titer of 5-HTP in the reported microbiological methods (
    • File Description:
      electronic resource
    • ISSN:
      2197-4365
    • Relation:
      https://doaj.org/toc/2197-4365
    • Accession Number:
      10.1186/s40643-025-00846-z
    • Accession Number:
      edsdoj.f576f309eb447689d8334b4fc750ab0