Abstract: Background: Acute heart failure is a major global health issue, contributing to significant morbidity, mortality, and healthcare costs in Sub-Saharan Africa, including Ethiopia. Despite its burden, comprehensive data on acute heart failure in East Africa remains scarce. Objective: This systematic review and meta-analysis aimed to synthesize existing evidence on the treatment outcome of acute heart failure and associated factors in East Africa with a focus on Ethiopia. Methods: Relevant studies were searched in major databases, including PubMed/Medline, Hinari, Science Direct, EMBASE, Scopus, AJOL, Cochrane Library, and local sources from July 5–25, 2024. Both published and unpublished studies in English were included without restrictions on publication date, following PRISMA-2020 protocols. Data quality was assessed using the Newcastle-Ottawa Scale, and meta-analysis was conducted using Stata version 18. Results: A total of 9 articles involving 1107 participants were included. The pooled mortality of acute heart failure was 16.36 % (95 % CI: 12.39, 20.33) with heterogeneity (I2) value of 85.86 %. Increased blood urea nitrogen (BUN), smoking, and hypotension were the factors significantly associated with the pooled mortality rate of acute heart failure. Conclusion: This review reveals a high mortality of acute heart failure among hospitalized patients in Ethiopia. Factors such as increased blood urea nitrogen (BUN), smoking, and hypotension contribute to death due to acute heart failure. Therefore, it is necessary to reduce the burden of acute heart failure and improve patient survival in Ethiopia by addressing the identified predictors of poor outcomes and integrating global best practices into local healthcare systems.
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