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Identification of cell cycle-targeting microRNAs through genome-wide screens

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  • Additional Information
    • Publication Information:
      Taylor & Francis, 2017.
    • Publication Date:
      2017
    • Abstract:
      By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting miRNAs to mouse xenograft models resulted in potent anti-tumorigenic effects without affecting animals' health. Here, we provide an in-depth description of our miRNA screening methodology, analyses of selected cell cycle-targeting miRNAs, and discuss why miRNA therapy might be a viable therapeutic option for cancer patients.
      Version of Record
    • File Description:
      application/pdf
    • Relation:
      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788471/pdf/; Cell Cycle
    • Accession Number:
      10.1080/15384101.2017.1380132
    • Accession Number:
      edshld.1.34868829