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Degraded tactile coding in the Cntnap2 mouse model of autism.

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  • Author(s): Wang, Han; Wang, Han; Feldman, Daniel
  • Source:
    Cell Reports; vol 43, iss 8
  • Document Type:
    Electronic Resource
  • Online Access:
    https://escholarship.org/uc/item/2qw0s3ct
    https://escholarship.org/content/qt2qw0s3ct/qt2qw0s3ct.pdf
  • Additional Information
    • Publisher Information:
      eScholarship, University of California 2024-08-27
    • Abstract:
      Atypical sensory processing is common in autism, but how neural coding is disrupted in sensory cortex is unclear. We evaluate whisker touch coding in L2/3 of somatosensory cortex (S1) in Cntnap2-/- mice, which have reduced inhibition. This classically predicts excess pyramidal cell spiking, but this remains controversial, and other deficits may dominate. We find that c-fos expression is elevated in S1 of Cntnap2-/- mice under spontaneous activity conditions but is comparable to that of control mice after whisker stimulation, suggesting normal sensory-evoked spike rates. GCaMP8m imaging from L2/3 pyramidal cells shows no excess whisker responsiveness, but it does show multiple signs of degraded somatotopic coding. This includes broadened whisker-tuning curves, a blurred whisker map, and blunted whisker point representations. These disruptions are greater in noisy than in sparse sensory conditions. Tuning instability across days is also substantially elevated in Cntnap2-/-. Thus, Cntnap2-/- mice show no excess sensory-evoked activity, but a degraded and unstable tactile code in S1.
    • Subject Terms:
      CP: Neuroscience; autism spectrum disorder; barrel cortex; layer 2/3; longitudinal imaging; representational drift; sensory coding; whisker; Animals; Membrane Proteins; Nerve Tissue Proteins; Somatosensory Cortex; Mice; Autistic Disorder; Disease Models; Animal; Vibrissae; Knockout; Touch; Inbred C57BL; Pyramidal Cells; Male; Proto-Oncogene Proteins c-fos; article
    • Availability:
      Open access content. Open access content
      public
    • Note:
      application/pdf
      Cell Reports vol 43, iss 8
    • Other Numbers:
      CDLER oai:escholarship.org:ark:/13030/qt2qw0s3ct
      qt2qw0s3ct
      https://escholarship.org/uc/item/2qw0s3ct
      https://escholarship.org/content/qt2qw0s3ct/qt2qw0s3ct.pdf
      info:doi/10.1016/j.celrep.2024.114612
      https://escholarship.org/
      1468512127
    • Contributing Source:
      UC MASS DIGITIZATION
      From OAIster®, provided by the OCLC Cooperative.
    • Accession Number:
      edsoai.on1468512127
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