Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Association Between Uric Acid to HDL-C Ratio and Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetes Mellitus: A Cross-Sectional Study

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Additional Information
    • Publisher Information:
      Dove Press 2025-05-07
    • Abstract:
      Xiangyun Zhu,1,2,* Han Yin,1,2,* Jing Han,1,2,* Xiaoyan Zhang,1,2 Qing Han,1,2 Weixia Sun,1,2 Yijun Liu,1,2 Wenxuan Tao,1,2 Xinliang Liu,3 Guofeng Wang,4 Ling Li1,2 1Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, People’s Republic of China; 2Pancreatic Research Institute, Southeast University, Nanjing, Jiangsu, 210009, People’s Republic of China; 3Department of Endocrinology, Lianyungang Affiliated Hospital of Nanjing Medical University, Lianyungang, 222000, People’s Republic of China; 4Department of Endocrinology, Xuyi People’s Hospital of Clinical College of Yangzhou University, Huai’an, Jiangsu, 211700, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ling Li, Email dr_liling@126.com; Guofeng Wang, Email wgfyyx@163.comBackground: Patients with type 2 diabetes mellitus (T2DM) exhibit an elevated risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD). The uric acid to high-density lipoprotein cholesterol ratio (UHR) has emerged as a novel metabolic biomarker implicated in MASLD pathogenesis. This study aimed to evaluate the association between UHR and MASLD in a T2DM population.Methods: In this cross-sectional study, we analyzed clinical data from 1081 T2DM patients (464 without MASLD, 617 with MASLD). Physiological and biochemical parameters were collected and analyzed. UHR was calculated as [uric acid (mg/dL)/HDL-C (mg/dL)] ×  100%. Univariate and multivariate logistic regression analyses were performed to examine the association between UHR and MASLD.Results: T2DM patients with MASLD had significantly higher UHR levels than those without MASLD (12.12[9.06– 16.83] vs 10.36[7.65– 14.08], p< 0.001). UHR showed a strong positive correlation with TG/HDL (r =0.673, p < 0.001), moderate correlations with TG (r = 0.516, p < 0.001) and TC/HDL (r =0.548, p < 0.001), weak bu
    • Subject Terms:
      Diabetes, Metabolic Syndrome and Obesity; Original Research; info:eu-repo/semantics/article
    • Availability:
      Open access content. Open access content
      info:eu-repo/semantics/openAccess
    • Note:
      text/html
      English
    • Other Numbers:
      NZDMP oai:dovepress.com/102739
      1519884082
    • Contributing Source:
      DOVE MEDL PRESS LTD
      From OAIster®, provided by the OCLC Cooperative.
    • Accession Number:
      edsoai.on1519884082
HoldingsOnline