- Document Number:
20190038650
- Appl. No:
16/074023
- Application Filed:
February 01, 2017
- Abstract:
The present disclosure provides compositions comprising trehalose, and optionally a trehalase inhibitor, for the treatment of atherosclerosis and liver steatosis.
- Claim:
1. A method for treating atherosclerosis in a subject in need thereof, the method comprising administering a therapeutically effective amount of a composition comprising trehalose, and optionally a trehalase inhibitor, to the subject.
- Claim:
2.-4. (canceled)
- Claim:
5. The method of claim 1, wherein the composition is administered orally or intravenously, wherein when the composition is administered orally, the trehalase inhibitor is present and when the composition is administered intravenously, the trehalase inhibitor is absent.
- Claim:
6.-7. (canceled)
- Claim:
8. The method of claim 1, wherein the trehalase inhibitor is validamycin.
- Claim:
9.-12. (canceled)
- Claim:
13. The method of claim 1, wherein the trehalose is administered at a dose of 5 to 50 grams per administration.
- Claim:
14. (canceled)
- Claim:
15. The method of claim 1, wherein the trehalose is administered at 8, 15 or 30 grams per day.
- Claim:
16. (canceled)
- Claim:
17. The method of claim 1, wherein treatment of atherosclerosis is measured by a reduction in atherosclerotic lesion area or a reduction in the signs and symptoms associated with atherosclerosis.
- Claim:
18.-20. (canceled)
- Claim:
21. The method of claim 1, wherein the subject is undergoing dialysis, wherein the composition is administered 1, 2, or 3 times per week following dialysis.
- Claim:
22. A method for treating liver steatosis in a subject in need thereof, the method comprising administering a therapeutically effective amount of a composition comprising trehalose, and optionally a trehalase inhibitor, to the subject.
- Claim:
23. The method of claim 22, wherein the composition is administered orally or intravenously, wherein when the composition is administered orally, the trehalase inhibitor is present and when the composition is administered intravenously, the trehalase inhibitor is absent.
- Claim:
24. The method of any of claim 22, wherein the trehalase inhibitor is validamycin.
- Claim:
25. The method of claim 22, wherein the trehalose is administered at a dose of 5 to 50 grams per administration.
- Claim:
26. The method of claim 22, wherein the trehalose is administered at 8, 15 or 30 grams per day.
- Claim:
27. The method of claim 22, wherein treatment of liver steatosis is a reduction in the signs and symptoms associated with liver steatosis or is measured by a reduction in fat mass or liver triglycerides.
- Claim:
28. The method of claim 22, wherein insulin resistance, obesity and/or diabetes is also treated.
- Claim:
29. A method for treating atherosclerosis and liver steatosis, simultaneously, in a subject in need thereof, the method comprising administering a therapeutically effective amount of a composition comprising trehalose, and optionally a trehalase inhibitor, to the subject.
- Claim:
30. The method of claim 29, wherein the composition is administered orally or intravenously, wherein when the composition is administered orally, the trehalase inhibitor is present and when the composition is administered intravenously, the trehalase inhibitor is absent.
- Claim:
31. The method of claim 29, wherein the trehalase inhibitor is validamycin.
- Claim:
32. The method of claim 29, wherein the trehalose is administered at a dose of 5 to 50 grams per administration.
- Claim:
33. The method of claim 29, wherein the trehalose is administered at 8, 15 or 30 grams per day.
- Claim:
34. The method of claim 29, wherein treatment of atherosclerosis is measured by a reduction in atherosclerotic lesion area or a reduction in the signs and symptoms associated with atherosclerosis.
- Current International Class:
61; 61; 61; 61; 61; 61
- Accession Number:
edspap.20190038650
Processing Request
No Comments.