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T-CELL EPITOPE POLYPEPTIDE OF FOOT AND MOUTH DISEASE VIRUS AND USES THEREOF

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  • Publication Date:
    March 13, 2025
  • Additional Information
    • Document Number:
      20250084131
    • Appl. No:
      18/824867
    • Application Filed:
      September 04, 2024
    • Abstract:
      A T-cell epitope polypeptide of foot and mouth disease virus (FMDV) having an amino acid sequence represented by one of SEQ ID Nos: 1-11: SEQ ID NO: 1: KGKPFNSKVIIATTNLYS; SEQ ID NO: 2: PLQNVYQLVQEVIDRVEL; SEQ ID NO: 3: VVMDDLGQNPDGKDFKYF; SEQ ID NO: 4: YNQQTVVVMDDLGQNPDG; SEQ ID NO: 5: GRTDSVWYCPPDPDHFDG; SEQ ID NO: 6: RGKSGQGKSFLANVLAQA; SEQ ID NO: 7: PDFNRLVSAFEELATGVK; SEQ ID NO: 8: AIRTGLDEAKPWYKLIKL; SEQ ID NO: 9: MSTKHGPDFNRLVSAFEE; SEQ ID NO: 10: MLDGRTMTDSDYRVF; and SEQ ID NO: 11: VLDEVIFSKHKGDTK.
    • Claim:
      1. A T-cell epitope polypeptide of foot and mouth disease virus (FMDV), the epitope polypeptide having an amino acid sequence represented by one of SEQ ID Nos: 1-11: [table included]
    • Claim:
      2. The epitope polypeptide of claim 1 having an amino acid sequence represented by one of SEQ ID Nos: 3, 6 and 7.
    • Claim:
      3. A construct, comprising a nucleic acid molecule encoding the T-cell epitope polypeptide of FMDV of claim 1.
    • Claim:
      4. A host cell, comprising the construct of claim 3, and/or a cell transformed or transfected by the construct.
    • Claim:
      5. A composition, comprising the T-cell epitope polypeptide of FMDV of claim 1 and a pharmaceutically acceptable vector or auxiliary.
    • Claim:
      6. The composition of claim 5, further comprising a recombinant protein comprising a T-cell epitope polypeptide of FMDV, RNA or DNA of an antigenic polypeptide of FMDV, or a vector for expression of the antigenic polypeptide by an attenuated virus or bacterium.
    • Claim:
      7. A pharmaceutical composition comprising the T-cell epitope polypeptide of FMDV of claim 1, a construct comprising the T-cell epitope polypeptide of FMDV, a host cell comprising the construct, or a composition comprising the T-cell epitope polypeptide of FMDV, and a pharmaceutically acceptable auxiliary.
    • Claim:
      8. An antibody comprising the T-cell epitope polypeptide of FMDV of claim 1 and a nucleic acid molecule of an antigen-binding fragment of the antibody or a vector or host cell comprising the nucleic acid molecule.
    • Claim:
      9. An immune composition comprising the T-cell epitope polypeptide of FMDV of claim 1 and an adjuvant.
    • Claim:
      10. The immune composition of claim 9, being in the form of a vaccine, a detection reagent, or a biological diagnostic reagent.
    • Current International Class:
      07; 61
    • Accession Number:
      edspap.20250084131