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Method for treating fungal infections using cell lytic enzymes

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  • Publication Date:
    December 13, 1977
  • Additional Information
    • Patent Number:
      4,062,941
    • Appl. No:
      05/689,700
    • Application Filed:
      May 24, 1976
    • Abstract:
      The present invention encompasses a method for treating fungal infections in animals comprising administering to animals in need of antifungal treatment an effective amount of fungal cell lytic enzymes extracted from Coprinus, Lycoperdon, or Bolbitius in conjunction with conventional antimycotic agents such as amphotericin B or Nystatin. The fungal cell lytic enzymes are extracted from Coprinus, Lycoperdon, and Bolbitius by conventional enzyme isolation techniques. These fungal cell lytic enzymes retain their activity in vivo, are relatively non toxic and destroy fungi by degrading fungal cell walls and weakening the fungal cell walls so that conventional antimycotic agents are far more effective. The method of the present invention is particularly useful in treating infections by opportunistic fungi such as Aspergillus fumigatus and Candida albicans.
    • Inventors:
      Davies, David Allen Lewis (High Wycombe, EN)
    • Assignees:
      G. D. Searle & Co. Ltd. (High Wycombe, EN)
    • Claim:
      What is claimed is
    • Claim:
      1. A method for treating fungal infections in animals comprising administering to an animal in need of antifungal treatment an effective amount of fungal cell lytic enzymes extracted from Coprinus or Lycoperdon.
    • Claim:
      2. A method for treating fungal infections in animals comprising administering to an animal in need of antifungal treatment an effective amount of fungal cell lytic enzymes extracted from Coprinus or Lycoperdon in conjunction with an antimycotic agent.
    • Claim:
      3. A method according to claim 2 for treating fungal infections in animals comprising administering to an animal in need of antifungal treatment an effective amount of fungal cell lytic enzymes extracted from Coprinus or Lycoperdon in conjunction with amphotericin-B or nystatin.
    • Claim:
      4. A method according to claim 2 wherein the fungal cell lytic enzyme is extracted from Lycoperdon pyriforme.
    • Claim:
      5. A method according to claim 2 wherein the fungal cell lytic enzyme is extracted from Coprinus comatus.
    • Claim:
      6. In a method for treating fungal infections by the administration of nystatin, amphotericin-B, or griseofulvin as antifungal agents, the improvement of which comprises the administration of effective amounts of fungal cell lytic anzymes extracted from Coprinus or Lycoperdon in conjunction with the antifungal agent.
    • Current U.S. Class:
      424/94
    • Current International Class:
      A61K 3748
    • Other References:
      kawai - Chem. Abst. vol. 73, (1970), p. 73196K.
    • Primary Examiner:
      Rosen, Sam
    • Attorney, Agent or Firm:
      McDonnell, John J.
    • Accession Number:
      edspgr.04062941