Graphene nanomesh based charge sensor

9,933,420

14/699329

April 29, 2015

A graphene nanomesh based charge sensor and method for producing a graphene nanomesh based charge sensor. The method includes generating multiple holes in graphene to create a graphene nanomesh with a patterned array of multiple holes; passivating an edge of each of the multiple holes of the graphene nanomesh to allow for functionalization of the graphene nanomesh; and functionalizing the passivated edge of each of the multiple holes of the graphene nanomesh with a chemical compound that facilitates chemical binding of a receptor of a target molecule to the edge of one or more of the multiple holes, wherein the receptor is a molecule that chemically binds to the target molecule, irrespective of the size of the target molecule.

International Business Machines Corporation (Armonk, NY, US); Egypt Nanotechnologies Center (EGNC) (Cairo-Alexandria Desert Road, EG)

International Business Machines Corporation (Armonk, NY, US), Egypt Nanotechnology Center (Cairo, EG)

1. A method for creating a graphene nanomesh based charge sensor for glucose molecules, comprising: generating a periodic patterned array of multiple holes in graphene to create a graphene nanomesh with a periodic patterned array of multiple holes, wherein the periodic patterned array of multiple holes is periodic in terms of hole size and lattice constant, and wherein each of the multiple holes in the periodic patterned array comprises: (i) a hole size in a range of approximately 5 nanometers to approximately 20 nanometers; (ii) a hole lattice constant gap ranging from approximately 0.1 electron volt to approximately 0.3 electron volt; and (iii) a pitch range of approximately 3× to approximately 6×; passivating an edge of each of the multiple holes in the periodic patterned array; functionalizing the passivated edge of each of the multiple holes in the periodic patterned array with a functional group selected from the group consisting of: O, H, OH, and NH 2 , wherein the functional group facilitates chemical binding of a 4-carboxyphenyl-boronic acid molecule to the passivated edge of one or more of the multiple holes in the periodic patterned array, wherein the 4-carobxyphenylboronic acid molecule binds through the 4-carboxy functionality of the 4-carobxylphenylboronic acid molecule to the functional group of the passivated edge of one or more of the multiple holes in the periodic patterned array of the graphene nanomesh to form at least one 4-carboxyphenylboronic acid ester linkage to the functional group of the passivated edge; and n-doping the graphene nanomesh via facilitating at least one reaction comprising at least one glucose molecule binding to each of the at least one 4-carboxyphenylboronic acid esters through a vicinal diol group of the glucose molecule, forming a cyclic ether and transferring a net charge to the graphene nanomesh, thereby producing a graphene nanomesh based charge sensor for at least one glucose molecule, wherein said n-doping the graphene nanomesh comprises effecting a specific charge transfer to the graphene nanomesh based on the at least one glucose molecule bound to the at least one 4-carobxyphenylboronic acid molecule, wherein the binding of the at least one glucose molecule to the at least one 4-carobxyphenylboronic acid molecule causes an increase in the conductance of the graphene nanomesh, and wherein a specific resistance sensitivity of the graphene nanomesh is determined based on the specific charge transfer.

2. The method of claim 1 , wherein each passivated edge of each of the multiple holes in the periodic patterned array binds with a 4-carobxyphenylboronic acid molecule.

3. The method of claim 1 , further comprising controlling a density of at least one receptor site by controlling at least one characteristic of a hole lattice of the periodic patterned array of multiple holes of the graphene nanomesh, wherein the at least one characteristic of the hole lattice is selected from the group consisting of hole size and lattice constant.

4. The method of claim 3 , wherein the at least one characteristic of the hole lattice of the periodic patterned array of multiple holes of the graphene nanomesh comprises hole size.

5. The method of claim 3 , wherein the at least one characteristic of the hole lattice of the periodic patterned array of multiple holes of the graphene nanomesh comprises lattice constant.

6. The method of claim 1 , wherein the pitch is 4×.

7. The method of claim 1 , wherein the functional group is OH.

8. The method of claim 1 , wherein the functional group is NH 2 .

9. The method of claim 1 , wherein the specific charge is between 0.1 electron and 1 electron transferred to the graphene nanomesh.

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