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Biomedical materials

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  • Publication Date:
    January 14, 2020
  • Additional Information
    • Patent Number:
      10532,114
    • Appl. No:
      15/418304
    • Application Filed:
      January 27, 2017
    • Abstract:
      A synthetic calcium phosphate-based biomedical material comprising gadolinium. The material may comprises a compound having the general chemical formula: Ca10−yGdy(PO4)6−x(SiO4)x(OH)2−c+y where 0
    • Inventors:
      ApaTech Limited (Elstree, Hertfordshire, GB); University Court of the University of Aberdeen (Aberdeen, Aberdeenshire, GB)
    • Assignees:
      ApaTech Limited (Elstree, Hertfordshire, GB), University Court of the University of Aberdeen (Aberdeen, Aberdeenshire, GB)
    • Claim:
      1. A method of improving MRI contrast in a calcium phosphate material comprising a calcium phosphate lattice, which method comprises substituting Gd 3+ into the lattice to produce a calcium phosphate material having the chemical formula: Ca 10−y Gd y (PO 4) 6−x (SiO 4) x (OH) 2−x+y wherein 0
    • Claim:
      2. A method comprising: magnetic resonance imaging a biomedical material comprising a gadolinium substituted calcium phosphate lattice having the chemical formula: Ca 10−y Gd y (PO 4) 6−x (SiO 4) x (OH) 2−x+y wherein 0
    • Claim:
      3. The method according to claim 1 , wherein the phase purity of the calcium phosphate material, as measured by X-ray diffraction using the whole pattern method, is at least 95%.
    • Claim:
      4. The method according to claim 1 , wherein 0.001
    • Claim:
      5. The method according to claim 1 , wherein 0.1
    • Claim:
      6. The method according to claim 1 , wherein 0
    • Claim:
      7. The method according to claim 1 , wherein 0
    • Claim:
      8. The method according to claim 1 , wherein x≥y.
    • Claim:
      9. The method according to claim 1 , wherein the gadolinium ion substitutes for the calcium ion in the calcium phosphate lattice.
    • Claim:
      10. The method according to claim 1 , wherein the silicate ion substitutes for the phosphate ion in the calcium phosphate lattice.
    • Claim:
      11. The method according to claim 2 , wherein the wherein the phase purity of the calcium phosphate material, as measured by X-ray diffraction using the whole pattern method, is at least 95%.
    • Claim:
      12. The method according to claim 2 , wherein 0.001
    • Claim:
      13. The method according to claim 2 , wherein 0.1
    • Claim:
      14. The method according to claim 2 , wherein 0
    • Claim:
      15. The method according to claim 2 , wherein 0
    • Claim:
      16. The method according to claim 2 , wherein x≥y.
    • Claim:
      17. The method according to claim 2 , wherein the gadolinium ion substitutes for the calcium ion in the calcium phosphate lattice.
    • Claim:
      18. The method according to claim 2 , wherein the silicate ion substitutes for the phosphate ion in the calcium phosphate lattice.
    • Claim:
      19. The method according to claim 2 , wherein the method is method of visualizing tissue repair.
    • Claim:
      20. The method according to claim 2 , wherein the method is a method of visualizing an implant with a cavity or void.
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    • Other References:
      Arcos et al., Crystal-Chemical Characteristics of Silicon-Neodymium Substituted Hydroxyapatites Studied by Combined X-ray and Neutron Powder Diffraction, Chem. Mater., 2005,17 (1), pp. 57-64. cited by applicant
      Boyer et al., Synthesis of phosphate-silicate apatites at atmospheric pressure, Solid State Ionics, vol. 95, Issues 1-2, Feb. 2, 1997, pp. 121-129. cited by applicant
      Carpena et al., Ca2+, PO, SiO44—coupled substitution in the apatitic structure: stability of the mono-silicated fluor-britholite, Comptes Rendus de l'Académie des Sciences—Series IIA—Earth and Planetary Science,vol. 333, Issue 7, Oct. 15, 2001, pp. 373-379. cited by applicant
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      Nakashima et al., Magnetic properties of gadolinium-doped beta-tricalcium phosphate, Journal of Alloys and Compounds, Elsevier Sequoia, Lausanne, CH, vol. 408-412, Feb. 9, 2006 (Feb. 9, 2006), pp. 761-765. cited by applicant
      Patel et al., In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect model, J Mater Sci Mater Med. May 2005;16(5):429-40. cited by applicant
      Rousselle, Etude de la formation du phosphate diphosphate de thorium (PDT) en milieu nitrique en vue d'une décontamination d'effluents de haute activité contenant des actinides, University of Paris, 2004, pp. 1, 6-12—Original and English translation. cited by applicant
      Skakle, Applications of X-ray powder diffraction in materials chemistry, Chem Rec. 2005;5(5)252-62. cited by applicant
    • Primary Examiner:
      Dickinson, Paul W
    • Attorney, Agent or Firm:
      K&L Gates LLP
    • Accession Number:
      edspgr.10532114