Efficacy of Nortriptyline‐Topiramate and Verapamil‐Paroxetine in Tinnitus Management: A Randomized Placebo‐Controlled Trial

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Author(s): Abouzari, Mehdi; Tawk, Karen; Kim, Joshua K; Larson, Eva D; Lin, Harrison W; Djalilian, Hamid R
Source:
Otolaryngology. 172(4)
Physical Description:
1348 - 1356
Subject Terms:
32 Biomedical and Clinical Sciences (for-2020); 3202 Clinical Sciences (for-2020); Clinical Research (rcdc); Brain Disorders (rcdc); Women's Health (rcdc); Clinical Trials and Supportive Activities (rcdc); 6.1 Pharmaceuticals (hrcs-rac); Humans (mesh); Tinnitus (mesh); Nortriptyline (mesh); Male (mesh); Female (mesh); Double-Blind Method (mesh); Middle Aged (mesh); Verapamil (mesh); Adult (mesh); Treatment Outcome (mesh); Drug Combinations (mesh); Drug Therapy; Combination (mesh); Aged (mesh); Severity of Illness Index (mesh); migraine; nortriptyline-topiramate; randomized clinical trial; tinnitus; verapamil-paroxetine; Humans (mesh); Tinnitus (mesh); Verapamil (mesh); Nortriptyline (mesh); Drug Combinations (mesh); Treatment Outcome (mesh); Drug Therapy; Combination (mesh); Severity of Illness Index (mesh); Double-Blind Method (mesh); Adult (mesh); Aged (mesh); Middle Aged (mesh); Female (mesh); Male (mesh); migraine; nortriptyline‐topiramate; randomized clinical trial; tinnitus; verapamil‐paroxetine; Humans (mesh); Tinnitus (mesh); Nortriptyline (mesh); Male (mesh); Female (mesh); Double-Blind Method (mesh); Middle Aged (mesh); Verapamil (mesh); Adult (mesh); Treatment Outcome (mesh); Drug Combinations (mesh); Drug Therapy; Combination (mesh); Aged (mesh); Severity of Illness Index (mesh); 1103 Clinical Sciences (for); Otorhinolaryngology (science-metrix); 3202 Clinical sciences (for-2020)
Document Type:
article
Online Access:
https://escholarship.org/uc/item/5tm6633k
https://escholarship.org/content/qt5tm6633k/qt5tm6633k.pdf

Additional Information
- Publication Information:
  eScholarship, University of California, 2025.
- Publication Date:
  2025
- Abstract:
  OBJECTIVE: To evaluate the efficacy of 2 drug combinations on tinnitus severity and associated stress, depression, sleep, and anxiety.STUDY DESIGN: A randomized, double-blind, placebo-controlled clinical trial conducted between 2019 and 2023 for an 8-week duration.SETTING: Single institution tertiary care center.METHODS: The study recruited adult patients with moderate to severe tinnitus for 6 months or more. In total, 81 patients were assessed for eligibility, 78 were enrolled and randomized, and 67 were included in the per-protocol analysis. Patients were randomized into 3 groups (1:1:1). Group NT received nortriptyline-topiramate, group VP received verapamil-paroxetine, and group P received placebo.RESULTS: A total of 19 patients in group NT, 22 in group VP, and 26 patients in group P were included in the per-protocol analysis. In group NT, the Tinnitus Functional Index (TFI) score decreased from 58.4 ± 13.9 (baseline) to 46.3 ± 17.5 (end-of-trial) (P
- File Description:
  application/pdf
- Accession Number:
  10.1002/ohn.1063
- Rights:
  public
- Accession Number:
  edssch.oai:escholarship.org:ark:/13030/qt5tm6633k

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Efficacy of Nortriptyline‐Topiramate and Verapamil‐Paroxetine in Tinnitus Management: A Randomized Placebo‐Controlled Trial

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