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9-Month observational Dia-Vacc study of vaccine type influence on SARS-CoV-2 immunity in dialysis and kidney transplant patients.
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- Author(s): Stumpf, Julian1,2 (AUTHOR); Anders, Leona3 (AUTHOR); Siepmann, Torsten4 (AUTHOR); Schwöbel, Jörg5 (AUTHOR); Karger, Claudia6 (AUTHOR); Lindner, Tom7 (AUTHOR); Faulhaber-Walter, Robert8 (AUTHOR); Langer, Torsten9 (AUTHOR); Escher, Katja10 (AUTHOR); Anding-Rost, Kirsten11 (AUTHOR); Seidel, Harald12 (AUTHOR); Hüther, Jan13 (AUTHOR); Pistrosch, Frank14 (AUTHOR); Martin, Heike15 (AUTHOR); Schewe, Jens16 (AUTHOR); Stehr, Thomas17 (AUTHOR); Meistring, Frank18 (AUTHOR); Paliege, Alexander1 (AUTHOR); Schneider, Daniel1 (AUTHOR); Bast, Ingolf3 (AUTHOR)
- Source:
Vaccine. Jan2024, Vol. 42 Issue 2, p120-128. 9p.
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- Abstract:
SARS-CoV-2mRNA vaccination related seroconversion rates are reduced in dialysis and kidney transplant patients. We evaluated nine months follow up data in our observational Dia-Vacc study exploring specific cellular (interferon-γ release assay) or/and humoral immune responses after 2x SARS-CoV-2mRNA vaccination in 880 participants including healthy medical personnel (125-MP), dialysis patients (595-DP), kidney transplant recipients (111-KTR), and apheresis patients (49-AP) with positive seroconversion (de novo IgA or IgG antibody positivity by ELISA) after eight weeks. Nine months after first vaccination, receptor binding domain (RBD) antibodies were still positive in 90 % of MP, 86 % of AP, but only 55 %/48 % of DP/KTR, respectively. Seroconversion remained positive in 100 % of AP and 99·2 % of MP, but 86 %/81 % of DP/KTR, respectively. Compared to MP, DP but not KTR or AP were at risk for a strong RBD decline, while KTR kept lowest RBD values over time. By multivariate analysis, BNT162b2mRNA versus 1273-mRNA vaccine type was an independent risk factor for a strong decline of RBD antibodies. Within the DP group, only time on dialysis was another (inverse) risk factor for the DP group. Compared to humoral immunity, T-cell immunity decline was less prominent. While seroconverted KTR reach lowest RBD values over time, DP are at specific risk for a strong decline of RBD antibodies after successful SARS-CoV-2mRNA vaccination, which also depends on the vaccine type being used. Therefore, booster vaccinations for DP should be considered earlier compared to normal population. [ABSTRACT FROM AUTHOR]
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