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A course-based undergraduate research experience in biochemistry that is suitable for students with various levels of preparedness.

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  • Author(s): Shelby SJ;Shelby SJ
  • Source:
    Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology [Biochem Mol Biol Educ] 2019 May; Vol. 47 (3), pp. 220-227. Date of Electronic Publication: 2019 Feb 22.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: John Wiley & sons Country of Publication: United States NLM ID: 100970605 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-3429 (Electronic) Linking ISSN: 14708175 NLM ISO Abbreviation: Biochem Mol Biol Educ Subsets: MEDLINE
    • Publication Information:
      Publication: 2002- : Hoboken, NJ : John Wiley & sons
      Original Publication: Oxford, UK : Elsevier, c2000-
    • Subject Terms:
      Curriculum* ; Learning* ; Research* ; Research Design* ; Universities*; Biochemistry/*education; Laboratories ; Students
    • Abstract:
      Due to resource limitations at predominantly undergraduate institutions, research opportunities for non-senior students can be limited. To provide opportunities for a variety of students to gain exposure to research, a course-based undergraduate research experience (CURE) was designed and conducted. Coupled inquiry was used to allow underclassmen and upperclassmen to participate. Students first utilized a bioinformatics approach to develop hypotheses concerning protein interactions with the receptor Mer tyrosine kinase (MERTK). Students designed experiments to identify specific sites of interactions with SH2-domain proteins utilizing an assortment of basic biochemical techniques. The semester culminated in students testing their hypotheses and producing manuscripts. Underclassmen that participated in the course also benefitted from mentor-mentee relationships developed with upperclassmen due to the collaborative nature of the course. The structure of the course also allows for further studies to be conducted based on novel findings and is highly adaptable to receptor tyrosine kinases found in other tissue types. © 2019 International Union of Biochemistry and Molecular Biology, 47(3):220-227, 2019.
      (© 2019 International Union of Biochemistry and Molecular Biology.)
    • Contributed Indexing:
      Keywords: Course-based undergraduate research experience; coupled inquiry; protein-protein interactions; undergraduate biochemistry
    • Publication Date:
      Date Created: 20190223 Date Completed: 20190906 Latest Revision: 20190906
    • Publication Date:
      20231215
    • Accession Number:
      10.1002/bmb.21227
    • Accession Number:
      30794348