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Asthma in paediatric intensive care in England residents: observational study.

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • Subject Terms:
      Intensive Care Units, Pediatric* ; Patient Admission*; Asthma/*epidemiology ; Asthma/*mortality ; Critical Care/*methods; Adolescent ; Child ; Child, Preschool ; England/epidemiology ; Female ; Hospital Mortality ; Humans ; Infant ; Infant, Newborn ; Male ; Prevalence ; Prospective Studies ; Respiration, Artificial ; Risk Factors ; Socioeconomic Factors
    • Abstract:
      Despite high prevalence of asthma in children in the UK, there were no prior report on asthma admissions in paediatric intensive care units (PICU). We investigated the epidemiology and healthcare resource utilisation in children with asthma presenting to PICUs in England. PICANet, a UK national PICU database, was queried for asthma as the primary reason for admission, of children resident in England from April 2006 until March 2013. There were 2195 admissions to PICU for a median stay of 1.4 days. 59% were males and 51% aged 0-4 years. The fourth and fifth most deprived quintiles represented 61% (1329) admissions and 73% (11) of the 15 deaths. Deaths were most frequent in 10-14 years age (n = 11, 73%), with no deaths in less than 5 years age. 38% of admissions (828/2193) received invasive ventilation, which was more frequent with increasing deprivation (13% (108/828) in least deprived to 31% (260/828) in most deprived) and with decreasing age (0-4-year-olds: 49%, 409/828). This first multi-centre PICU study in England found that children from more deprived neighbourhoods represented the majority of asthma admissions, invasive ventilation and deaths in PICU. Children experiencing socioeconomic deprivation could benefit from enhanced asthma support in the community.
      (© 2022. The Author(s).)
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    • Grant Information:
      MC_PC_19004 United Kingdom MRC_ Medical Research Council; United Kingdom BHF_ British Heart Foundation; United Kingdom DH_ Department of Health; MR/R004498/1 United Kingdom MRC_ Medical Research Council; United Kingdom CSO_ Chief Scientist Office; AUK-PG-2012-178 Asthma UK; United Kingdom WT_ Wellcome Trust
    • Publication Date:
      Date Created: 20220126 Date Completed: 20220304 Latest Revision: 20220323
    • Publication Date:
      20240105
    • Accession Number:
      PMC8789863
    • Accession Number:
      10.1038/s41598-022-05414-5
    • Accession Number:
      35079067