Preliminary Report on the Influence of Acute Inflammation on Adiponectin Levels in Older Inpatients with Different Nutritional Status.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Adiponectin*/blood ; Adiponectin*/chemistry ; Malnutrition*/metabolism ; Nutritional Status*; Aged ; Humans ; Geriatric Assessment ; Inflammation ; Inpatients ; Nutrition Assessment

Inflammation can be triggered by a variety of factors, including pathogens, damaged cells, and toxic compounds. It is a biological response of the immune system, which can be successfully assessed in clinical practice using some molecular substances. Because adiponectin, a hormone released by adipose tissue, influences the development of inflammation, its evaluation as a potential measure of inflammation in clinical practice is justified. In the present contribution, statistical comparison of adiponectin concentration and selected molecular substances recognized in clinical practice as measures of inflammation were utilized to demonstrate whether adipose tissue hormones, as exemplified by adiponectin, have the potential to act as a measure of rapidly changing inflammation when monitoring older hospitalized patients in the course of bacterial infection. The study showed no statistically significant differences in adiponectin levels depending on the rapidly changing inflammatory response in its early stage. Interestingly, the concentration of adiponectin is statistically significantly higher in malnourished patients than in people with normal nutritional levels, assessed based on the MNA. According to the results obtained, adiponectin is not an effective measure of acute inflammation in clinical practice. However, it may serve as a biomarker of malnutrition in senile individuals.

J Clin Invest. 2010 Jun;120(6):1809-11. (PMID: 20501951)
Lipids Health Dis. 2019 Dec 23;18(1):227. (PMID: 31870374)
Clin Chim Acta. 2007 May 1;380(1-2):24-30. (PMID: 17343838)
Diabetes Metab Syndr Obes. 2020 Feb 28;13:591-596. (PMID: 32184638)
Shock. 2012 Aug;38(3):243-8. (PMID: 22744305)
Sci Rep. 2021 Jul 5;11(1):13809. (PMID: 34226603)
Obesity (Silver Spring). 2017 Oct;25(10):1776-1785. (PMID: 28834421)
Hepatology. 2008 Aug;48(2):374-84. (PMID: 18666256)
Oxid Med Cell Longev. 2017;2017:3496043. (PMID: 28255425)
Nutrients. 2021 Aug 12;13(8):. (PMID: 34444924)
BMC Geriatr. 2022 Jun 3;22(1):479. (PMID: 35659569)
Sci Rep. 2021 Dec 1;11(1):23194. (PMID: 34853395)
Cells. 2022 Jan 21;11(3):. (PMID: 35159168)
Sci Rep. 2017 Jul 26;7(1):6619. (PMID: 28747790)
Nutrients. 2021 Apr 02;13(4):. (PMID: 33918360)
Front Immunol. 2023 Sep 01;14:1244586. (PMID: 37724101)
J Proteomics. 2011 Oct 19;74(11):2313-23. (PMID: 21718814)
Rev Endocr Metab Disord. 2014 Mar;15(1):1-10. (PMID: 24026768)
Oncotarget. 2017 Dec 14;9(6):7204-7218. (PMID: 29467962)
Eur J Breast Health. 2018 Dec 19;15(1):13-17. (PMID: 30816355)
BMC Endocr Disord. 2021 Jul 8;21(1):147. (PMID: 34233657)
J Feline Med Surg. 2022 Dec;24(12):e595-e602. (PMID: 36350675)
Aging Clin Exp Res. 2023 May;35(5):925-935. (PMID: 36995460)
Aging Clin Exp Res. 2017 Aug;29(4):621-629. (PMID: 27688246)
Nutrients. 2021 Apr 21;13(5):. (PMID: 33919141)
Gynecol Endocrinol. 2020 Jul;36(7):620-625. (PMID: 32233812)
Clin Exp Immunol. 2003 Oct;134(1):107-10. (PMID: 12974762)
PLoS One. 2012;7(9):e45693. (PMID: 23029185)
Front Cardiovasc Med. 2015 Mar 05;2:7. (PMID: 26664879)
J Cachexia Sarcopenia Muscle. 2023 Feb;14(1):270-278. (PMID: 36401062)
Acta Clin Belg. 2023 Aug;78(4):285-290. (PMID: 36398376)
Front Immunol. 2023 Jul 26;14:1237729. (PMID: 37564640)
Int J Mol Sci. 2020 Feb 12;21(4):. (PMID: 32059381)
Nutrition. 1999 Feb;15(2):116-22. (PMID: 9990575)
Aging Med (Milton). 2020 Aug 09;3(3):205-213. (PMID: 33103041)
BMC Geriatr. 2019 Jul 17;19(1):190. (PMID: 31315578)
Ann Afr Med. 2019 Jul-Sep;18(3):121-126. (PMID: 31417011)
Sci Rep. 2020 Mar 27;10(1):5598. (PMID: 32221363)
Antioxidants (Basel). 2023 Feb 24;12(3):. (PMID: 36978817)
Int J Clin Pract. 2014 Mar;68(3):290-3. (PMID: 24118661)
Blood. 2022 Apr 7;139(14):2130-2144. (PMID: 34624098)
Drugs Aging. 2023 Jun;40(6):499-526. (PMID: 36976501)
Eur Heart J. 2006 May;27(10):1174-81. (PMID: 16611671)

Keywords: MNA; adiponectin; bacterial infection; inflammation; malnutrition; nutritional status; older inpatients; oxidative stress in infection

0 (Adiponectin)

Date Created: 20240224 Date Completed: 20240226 Latest Revision: 20240308

20240309

PMC10889142

10.3390/ijms25042016

38396693