Mind, Mood and Microbiota-Gut-Brain Axis in Psychiatric Disorders.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Depressive Disorder, Major* ; Mental Disorders*/drug therapy ; Probiotics*/therapeutic use ; Probiotics*/pharmacology; Humans ; Brain-Gut Axis ; Brain/physiology ; Central Nervous System ; Prebiotics

Psychiatric disorders represent a primary source of disability worldwide, manifesting as disturbances in individuals' cognitive processes, emotional regulation, and behavioral patterns. In the quest to discover novel therapies and expand the boundaries of neuropharmacology, studies from the field have highlighted the gut microbiota's role in modulating these disorders. These alterations may influence the brain's processes through the brain-gut axis, a multifaceted bidirectional system that establishes a connection between the enteric and central nervous systems. Thus, probiotic and prebiotic supplements that are meant to influence overall gut health may play an insightful role in alleviating psychiatric symptoms, such as the cognitive templates of major depressive disorder, anxiety, or schizophrenia. Moreover, the administration of psychotropic drugs has been revealed to induce specific changes in a microbiome's diversity, suggesting their potential utility in combating bacterial infections. This review emphasizes the intricate correlations between psychiatric disorders and the gut microbiota, mentioning the promising approaches in regard to the modulation of probiotic and prebiotic treatments, as well as the antimicrobial effects of psychotropic medication.

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Keywords: MDD; antidepressants; antipsychotics; autism; brain–gut axis; gut microbiota; probiotics

0 (Prebiotics)

Date Created: 20240328 Date Completed: 20240329 Latest Revision: 20240330

20240330

PMC10970241

10.3390/ijms25063340

38542314