Role of Sensory Nerves in Pulmonary Fibrosis.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Pulmonary Fibrosis*/metabolism ; Hypertension, Pulmonary*/metabolism; Humans ; Lung/metabolism ; Afferent Pathways ; Respiratory Mucosa/metabolism

Pulmonary fibrosis results from the deposition and proliferation of extracellular matrix components in the lungs. Despite being an airway disorder, pulmonary fibrosis also has notable effects on the pulmonary vasculature, with the development and severity of pulmonary hypertension tied closely to patient mortality. Furthermore, the anatomical proximity of blood vessels, the alveolar epithelium, lymphatic tissue, and airway spaces highlights the need to identify shared pathogenic mechanisms and pleiotropic signaling across various cell types. Sensory nerves and their transmitters have a variety of effects on the various cell types within the lungs; however, their effects on many cell types and functions during pulmonary fibrosis have not yet been investigated. This review highlights the importance of gaining a new understanding of sensory nerve function in the context of pulmonary fibrosis as a potential tool to limit airway and vascular dysfunction.

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CDA #931652 American Heart Association

Keywords: calcitonin gene-related peptide; cough; edema sleep apnea; pericytes; pulmonary fibrosis; pulmonary hypertension; sensory nerves; substance P

Date Created: 20240328 Date Completed: 20240329 Latest Revision: 20240330

20240330

PMC10971555

10.3390/ijms25063538

38542511