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Academic Journal

Proteomic analysis of machine perfusion solution from brain dead donor kidneys reveals that elevated complement, cytoskeleton and lipid metabolism proteins are associated with 1-year outcome

Subjects: biomarker discovery; complement activation; donation after brain death

  • Source: van Leeuwen, L L, Spraakman, N A, Brat, A, Huang, H, Thorne, A M, Bonham, S, van Balkom, B W M, Ploeg, R J, Kessler, B M & Leuvenink, H G D 2021, 'Proteomic analysis of machine perfusion solution from

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Academic Journal

Activation of the Innate Immune System in Brain-Dead Donors Can Be Reduced by Luminal Intestinal Preservation During Organ Procurement Surgery:A Porcine Model

Subjects: brain dead donor; C3a; innate immune system

  • Source: Weiss, M G, de Jong, A M, Seegert, H, Moeslund, N, Maassen, H, Schjalm, C, de Boer, E, Leuvenink, H, Mollnes, T E, Eijken, M, Keller, A K, Dijkstra, G, Jespersen, B & Pischke, S E 2024, 'Activation of

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Academic Journal

Clinical descriptors of disease trajectories in patients with traumatic brain injury in the intensive care unit (CENTER-TBI):a multicentre observational cohort study

Subjects: Humans; Biomarkers; Brain Injuries

  • Source: CENTER-TBI participants and investigators, Åkerlund, C A I, Holst, A, Bhattacharyay, S, Stocchetti, N, Steyerberg, E, Smielewski, P, Menon, D K, Ercole, A & Nelson, D W 2024, 'Clinical descriptors of

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Academic Journal

Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain

Subjects: Animals; Humans; Mice

  • Source: Stroo, E, Janssen, L, Sin, O, Hogewerf, W, Koster, M, Harkema, L, Youssef, S A, Beschorner, N, Wolters, A H G, Bakker, B, Becker, L, Garrett, L, Marschall, S, Hoelter, S M, Wurst, W, Fuchs, H,

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Academic Journal

Opioid precursor protein isoform is targeted to the cell nuclei in the human brain

Subjects: Neuropeptide precursor protein; Prodynorphin; Alternative splicing

  • Source: Kononenko , O , Bazov , I , Watanabe , H , Gerashchenko , G , Dyachok , O , Verbeek , D S , Alkass , K , Druid , H , Andersson , M , Mulder , J , Svenningsen , A F , Rajkowska , G , Stockmeier , C A ,

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Academic Journal

Paclitaxel plus Eftilagimod Alpha, a Soluble LAG-3 Protein, in Metastatic, HR+ Breast Cancer:Results from AIPAC, a Randomized, Placebo Controlled Phase 2b Trial

  • Source: Wildiers, H, Armstrong, A, Cuypere, E, Dalenc, F, Dirix, L, Chan, S, Marme, F, Schröder, C P, Huober, J, Duhoux, F P, Vuylsteke, P, Jager, A, Brain, E, Kuemmel, S,

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Academic Journal

Identification of Autophagy as a Functional Target Suitable for the Pharmacological Treatment of Mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN) In Vitro

Subjects: ABT-737; autophagy; C19orf12

  • Source: Zanuttigh, E, Derderian, K, Güra, M A, Geerlof, A, Di Meo, I, Cavestro, C, Hempfling, S, Ortiz-Collazos, S, Mauthe, M, Kmieć, T, Cammarota, E, Panzeri, M C, Klopstock, T, Sattler, M, Winkelmann, J,

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Academic Journal

Phenylketonuria:reduced tyrosine brain influx relates to reduced cerebral protein synthesis

Subjects: Phenylketonuria; Phenylalanine; Tyrosine

  • Source: de Groot , M J , Hoeksma , M , Reijngoud , D-J , de Valk , H W , Paans , A M J , Sauer , P J J & van Spronsen , F J 2013 , ' Phenylketonuria : reduced tyrosine brain

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Academic Journal

Drosophila Vps13 Is Required for Protein Homeostasis in the Brain

Subjects: GOLGI MATRIX PROTEIN; CHOREA-ACANTHOCYTOSIS; COHEN-SYNDROME

  • Source: Vonk , J J , Yeshaw , W M , Pinto , F , Faber , A I E , Lahaye , L L , Kanon , B , van der Zwaag , M , Velayos-Baeza , A , Freire , R , van IJzendoorn , S C , Grzeschik , N A & Sibon , O C M 2017 , '

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