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Academic Journal

APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease

Subjects: AAV; Alzheimer disease; APOE

  • Source: Jackson, R J, Keiser, M S, Meltzer, J C, Fykstra, D P, Dierksmeier, S E, Hajizadeh, S, Kreuzer, J, Morris, R, Melloni, A, Nakajima, T, Tecedor, L, Ranum, P T, Carrell, E, Chen, Y H, Nishtar, M A,

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Academic Journal

Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction

Subjects: Humans; Tauopathies/drug therapy; tau Proteins/metabolism

  • Source: Pinzi, L, Conze, C, Bisi, N, Torre, G D, Soliman, A, Monteiro-Abreu, N, Trushina, N I, Krusenbaum, A, Dolouei, M K, Hellwig, A, Christodoulou, M S, Passarella, D, Bakota, L, Rastelli, G & Brandt, R

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Academic Journal

The γ-secretase substrate proteome and its role in cell signaling regulation

Subjects: Mice; Animals; Humans

  • Source: Hou, P, Zielonka, M, Serneels, L, Martinez-Muriana, A, Fattorelli, N, Wolfs, L, Poovathingal, S, T'Syen, D, Balusu, S, Theys, T, Fiers, M, Mancuso, R, Howden, A J M & De Strooper, B 2023, 'The

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Academic Journal

Comprehensive genetic screening of early-onset dementia patients in an Austrian cohort-suggesting new disease-contributing genes

Subjects: Humans; Aged; Alzheimer Disease/genetics

  • Source: Silvaieh, S, König, T, Wurm, R, Parvizi, T, Berger-Sieczkowski, E, Goeschl, S, Hotzy, C, Wagner, M, Berutti, R, Sammler, E, Stögmann, E & Zimprich, A 2023, 'Comprehensive genetic screening of

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Academic Journal

Peripheral Vascular Responses to Acetylcholine as a Predictive Tool for Response to Cholinesterase Inhibitors in Alzheimer's Disease

Subjects: Cholinesterase; Acetylcholine; blood flow

  • Source: Connelly, P, Adams, F, Tayar, Z I & Khan, F 2019, 'Peripheral Vascular Responses to Acetylcholine as a Predictive Tool for Response to Cholinesterase Inhibitors in

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Academic Journal

Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway

Subjects: Alzheimer disease; APP; C99

  • Source: González, A E, Muñoz, V C, Cavieres, V A, Bustamante, H A, Cornejo, V-H, Januário, Y C, González, I, Hetz, C, daSilva, L L, Rojas-Fernández, A, Hay, R T, Mardones, G A & Burgos, P V 2017,

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Academic Journal

Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue

Subjects: Autophagy; mitochondria; mitophagy

  • Source: Watzlawik, J O, Hou, X, Richardson, T, Lewicki, S L, Siuda, J, Wszolek, Z K, Cook, C N, Petrucelli, L, DeTure, M, Dickson, D W, Antico, O, Muqit, M M K, Fishman, J B, Pirani, K, Kumaran, R, Polinski,

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Academic Journal

The MK2 cascade mediates transient alteration in mGluR-LTD and spatial learning in a murine model of Alzheimer's disease

Subjects: APP/PS1 mouse; Arc/Arg3.1; hippocampus

  • Source: Privitera, L, Hogg, E L, Lopes, M, Domingos, L B, Gaestel, M, Müller, J, Wall, M J & Corrêa, S A L 2022, 'The MK2 cascade mediates transient alteration in mGluR-LTD and spatial learning in a murine

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Academic Journal

Brain energy rescue:an emerging therapeutic concept for neurodegenerative disorders of ageing

Subjects: Alzheimer's disease; Drug development; Outcomes research

  • Source: Cunnane, S C, Trushina, E, Morland, C, Prigione, A, Casadesus, G, Andrews, Z B, Beal, M F, Bergersen, L H, Brinton, R D, de la Monte, S, Eckert, A, Harvey, J, Jeggo, R, Jhamandas, J H, Kann, O,

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Academic Journal

Erythematous Macular Eruption in an Older Woman

Subjects: Dermatology; Hematology; Oncology

  • Source: McLaughlin, D, Kernohan, N & Tauro, S 2019, 'Erythematous Macular Eruption in an Older Woman', JAMA Oncology, vol. 5, no. 4, pp. 565-566. https://doi.org/10.1001/jamaoncol.2018.5317

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  • 1-10 of  13 results for ""Alzheimer disease""