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Academic Journal

The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis

Subjects: Cisplatin; Cholesterol; Cytochromes c

  • Source: Holloway , J , Seeley , A , Cobbe , N , Turkington , R C , Longley , D B & Evergren , E 2024 , ' The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect

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Academic Journal

Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma

Subjects: adenocarcinoma - drug therapy - metabolism - pathology; antineoplastic Agents - pharmacology; apoptosis - drug effects

  • Source: Stevenson , L , Cairns , L , Li , X , Jammula , S , Taylor , H , Douglas , R , McCabe , N , Gavory , G , Jacq , X , Fitzgerald , R C , Kennedy , R D , Harrison , T & Turkington , R C 2024 , '

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Academic Journal

Ruthenium drug BOLD-100 regulates BRAFMT colorectal cancer cell apoptosis through AhR/ROS/ATR signaling axis modulation

Subjects: ruthenium drug; BOLD-100; BRAFMT

  • Source: Griffin , D , Carson , R , Moss , D , Sessler , T , Lavin , D , Tiwari , V , Karelia , S , Kennedy , R , Savage , K I , McDade , S , Carie , A , Pankovich , J , Bazett , M & Van Schaeybroeck , S 2024

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Academic Journal

Apoptosis and autophagy markers predict survival in neoadjuvant treated oesophageal adenocarcinoma patients

Subjects: Humans; Prognosis; Adenocarcinoma - pathology

  • Source: El Mashed , S , O'Donovan , T R , Kay , E , O'Grady , A , McManus , D , Turkington , R C & McKenna , S L 2022 , ' Apoptosis and autophagy markers predict survival in

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Academic Journal

Bioinformatics analysis of miRNAs targeting TRAF5 in DLBCL involving in NF- κ B signaling pathway and affecting the apoptosis and signal transduction

Subjects: Humans; TNF Receptor-Associated Factor 5; NF-kappa B

  • Source: Li , C , Huang , L , Wen , Y , Yi , M & Gao , M 2022 , ' Bioinformatics analysis of miRNAs targeting TRAF5 in DLBCL involving in NF- κ B signaling pathway and affecting the

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Academic Journal

Bithionol eliminates acute myeloid leukaemia stem-like cells by suppressing NF-κB signalling and inducing oxidative stress, leading to apoptosis and ferroptosis

Subjects: Acute myeloid leukaemia; AML; bone marrow

  • Source: Dias , I R S B , Costa , R G A , Rodrigues , A C B D C , Silva , S L R , Oliveira , M D S , Soares , M B P , Dias , R B , Valverde , L F , Gurgel Rocha , C A , Cairns , L V , Mills , K I & Bezerra , D

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Academic Journal

Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features

Subjects: Humans; Transforming Growth Factor beta; Apoptosis/genetics

  • Source: Flanagan , D J , Amirkhah , R , Vincent , D F , Gundaz , N , Gentaz , P , Cammareri , P , McCooey , A J , McCorry , A M B , Fisher , N C , Davis , H L , Ridgway , R A , Lohuis , J , Leach , J D G ,

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Academic Journal

A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

Subjects: apoptosis; caspase-8; DISC

  • Source: Humphreys , L M , Fox , J P , Higgins , C A , Majkut , J , Sessler , T , McLaughlin , K , McCann , C , Roberts , J Z , Crawford , N T , McDade , S S , Scott , C J , Harrison , T & Longley , D B 2020 ,

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Academic Journal

Oxidative stress induced by selenium deficiency contributes to inflammation, apoptosis and necroptosis in the lungs of calves

Subjects: Cell Biology; Clinical Biochemistry; Molecular Biology

  • Source: Mu , J , Lei , L , Zheng , Y , Liu , J , Li , J , Li , D , Wang , G & Liu , Y 2023 , ' Oxidative stress induced by selenium deficiency contributes to inflammation,

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Academic Journal

Bcl-xL is a key mediator of apoptosis following KRAS G12C inhibition in KRAS G12C -mutant colorectal cancer

Subjects: Cancer Research; Oncology; /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being

  • Source: Khawaja , H , Briggs , R , Latimer , C H , Rassel , M , Griffin , D , Hanson , L , Bardelli , A , Di Nicolantonio , F , McDade , S S , Scott , C J , Lambe , S , Maurya , M , Lindner , A U , Prehn , J

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