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Small molecule inhibition of CBX4/7 hypersensitises homologous recombination-impaired cancer to radiation by compromising CtIP-mediated DNA end resection

• Authors : Osborne, Hugh; Foster, Benjamin; Al-Hazmi, Hazim

Subjects: cancer; DNA repair; DNA end resection

• Source: Osborne , H , Foster , B , Al-Hazmi , H , Meyer , S , Larrosa , I & Schmidt , C 2024 , ' Small molecule inhibition of CBX4/7 hypersensitises homologous

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Homologous recombination deficiency in newly diagnosed FIGO stage III/IV high-grade epithelial ovarian cancer: a multi-national observational study

• Authors : Morgan, Robert D; Clamp, Andrew R; Barnes, Bethany M

• Source: Morgan , R D , Clamp , A R , Barnes , B M , Timms , K , Schlecht , H , Yarram-Smith , L , Wallis , Y , Valganon-Petrizan , M , Macmahon , S , White , R , Morgan , S , Mckenna , S , Hudson , E ,

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Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification

• Authors : Clarke, Robert

Subjects: ResearchInstitutes_Networks_Beacons/mcrc; name=Manchester Cancer Research Centre

• Source: Clarke , R 2022 , ' Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and

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Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model

• Authors : Borst, Gerben R; Kumareswaran, Ramya; Yücel, Hatice

Subjects: Hypoxia; Neoadjuvant treatment; Olaparib

• Source: Borst , G R , Kumareswaran , R , Yücel , H , Telli , S , Do , T , McKee , T , Zafarana , G , Jonkers , J , Verheij , M , O'Connor , M J , Rottenberg , S & Bristow , R G 2017 , ' Neoadjuvant olaparib

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Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks.

• Authors : Aymard, François; Bugler, Beatrix; Schmidt, Christine

Subjects: DSB repair; NHEJ; HR

• Source: Aymard , F , Bugler , B , Schmidt , C , Guillou , E , Caron , P , Briois , S , Iacovoni , J S , Daburon , V , Miller , K M , Jackson , S P & Legube , G 2014 , ' Transcriptionally active chromatin

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On the mechanism of hyperthermia-induced BRCA2 protein degradation

• Authors : Van Den Tempel, Nathalie; Zelensky, Alex N.; Odijk, Hanny

Subjects: BRCA2; Homologous recombination; HSP90

• Source: Van Den Tempel , N , Zelensky , A N , Odijk , H , Laffeber , C , Schmidt , C K , Brandsma , I , Demmers , J , Krawczyk , P M & Kanaar , R 2019 , ' On the mechanism of hyperthermia-induced BRCA2

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Epithelial ovarian cancer risk: a review of the current genetic landscape

• Authors : Flaum, Nicola; Crosbie, Emma; Edmondson, Richard

Subjects: ovarian cancer; BRCA; genetic risk

• Source: Flaum , N , Crosbie , E , Edmondson , R , Smith , M J & Evans , D G 2019 , ' Epithelial ovarian cancer risk: a review of the current genetic landscape ' , Clinical Genetics .

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SAMHD1 sheds moonlight on DNA double-strand break repair

• Authors : Cabello Lobato, Maria Jose; Wang, Siyue; Schmidt, Christine

Subjects: SAMHD1; DNA double-strand breaks; Homologous recombination (HR)

• Source: Cabello Lobato , M J , Wang , S & Schmidt , C 2017 , ' SAMHD1 sheds moonlight on DNA double-strand break repair ' , Trends in genetics : TIG . https://doi.org/10.1016/j.tig.2017.09.007

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Is reflex germline BRCA1/2 testing necessary in women diagnosed with non-mucinous high-grade epithelial ovarian cancer aged 80 years or older?

• Authors : Burghel, George; Flaum, Nicola; Bulman, Michael

Subjects: BRCA1; BRCA2; epithelial ovarian cancer

• Source: Burghel , G , Flaum , N , Bulman , M , Smith , P , Clamp , A R , Hasan , J , Mitchell , C L , Salih , Z , Woodward , E R , Lalloo , F , Crosbie , E , Edmondson , R , Schlecht , H , Jayson , G C &

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High detection rate from genetic testing in BRCA-negative women with familial epithelial ovarian cancer

• Authors : Flaum, Nicola; Crosbie, Emma J; Edmondson, Richard

Subjects: BRCA1 Protein/genetics; BRCA2 Protein/genetics; Carcinoma

• Source: Flaum , N , Crosbie , E J , Edmondson , R , Woodward , E R , Lalloo , F , Smith , M J , Schlecht , H & Evans , D G 2022 , ' High detection rate from genetic testing in BRCA-negative women with

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