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Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance

• Authors : Tooke, Catherine L; Hinchliffe, Philip; Bonomo, Robert A.

Subjects: Serine β-lactamase; acyl-enzyme; enzyme catalysis

• Source: Tooke , C L , Hinchliffe , P , Bonomo , R A , Schofield , C J , Mulholland , A J & Spencer , J 2021 , ' Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-

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Sensing Enzyme Activation Heat Capacity at the Single-Molecule Level Using Gold-Nanorod-Based Optical Whispering Gallery Modes

Subjects: single molecules; whispering gallery modes; plasmonics

• Source: et al. 2021 , ' Sensing Enzyme Activation Heat Capacity at the Single-Molecule Level Using Gold-Nanorod-Based Optical Whispering Gallery Modes ' , ACS Applied Nano

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Chemical Mapping Exposes the Importance of Active Site Interactions in Governing the Temperature Dependence of Enzyme Turnover

• Authors : Winter, Sam; Jones, Hannah B L; Răsădean, Dora M.

Subjects: enzyme; catalysis; protein dynamics

• Source: Winter , S , Jones , H B L , Răsădean , D M , Crean , R M , Van der Kamp , M W & Pudney , C R 2021 , ' Chemical Mapping Exposes the Importance of Active Site Interactions in Governing the

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Rigidifying a De Novo Enzyme Increases Activity and Induces a Negative Activation Heat Capacity

• Authors : Hindson, S A; Bunzel, H A; Frank, B

Subjects: /dk/atira/pure/core/keywords/brissynbio; name=BrisSynBio; /dk/atira/pure/core/keywords/biodesign_SRI

• Source: Hindson , S A , Bunzel , H A , Frank , B , Svistunenko , D A , Williams , C , Van Der Kamp , M W , Mulholland , A J , Pudney , C R & Anderson , J L R 2021 , ' Rigidifying a De Novo

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Comparing the efficacy of cipaglucosidase alfa plus miglustat with other enzyme replacement therapies for late-onset Pompe disease:a network meta-analysis utilizing patient-level and aggregate data

• Authors : Shohet, Simon; Hummel, Noemi; Fu, Shuai

Subjects: /dk/atira/pure/core/keywords/fohsheb; name=HEHP@Bristol

• Source: Shohet , S , Hummel , N , Fu , S , Keyzor , I , MacCulloch , A , Johnson , N , Castelli , J , Czarny-Ozga , I , Mozaffar , T & Thom , H H Z 2024 , ' Comparing the efficacy of cipaglucosidase alfa plus

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Dynamical responses predict a distal site that modulates activity in an antibiotic resistance enzyme

• Authors : Beer, Michael; Oliveira, A; Tooke, Catherine L

Subjects: /dk/atira/pure/core/keywords/bcompb; name=BcompB; D-NEMD Simulations

• Source: Beer , M , Oliveira , A , Tooke , C L , Hinchliffe , P , Li , A T Y , Balega , B , Spencer , J & Mulholland , A J 2024 , ' Dynamical responses predict a distal site that modulates activity in an

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Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution of a β-lactamase

• Authors : Frohlich, Christopher; Bunzel, Adrian A; Buda, Karol

• Source: Frohlich , C , Bunzel , A A , Buda , K , Mulholland , A J , Van der Kamp , M W , Johnsen , P J , Leiros , H-K S & Tokuriki , N 2024 , ' Epistasis Arises from Shifting the Rate-Limiting Step during

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Improving Nitrofurantoin Resistance Prediction in Escherichia coli from Whole Genome Sequence by Integrating NfsA/B Enzyme Assays

• Authors : Dulyayangkul, Punyawee; Sealey, Jordan E; Lee, Winnie W Y

• Source: Dulyayangkul , P , Sealey , J E , Lee , W W Y , Satapoomin , A , Reding , C , Heesom , K J , Williams , P B & Avison , M B 2024 , ' Improving Nitrofurantoin Resistance Prediction in Escherichia coli

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Cooperative Conformational Transitions Underpin the Activation Heat Capacity in the Temperature Dependence of Enzyme Catalysis

• Authors : Walker, Emma J; Hamill, Carlin J; Crean, Rory

• Source: Walker , E J , Hamill , C J , Crean , R , Connolly , M S , Warrender , A K , Kraakman , K L , Prentice , E J , Steyn-Ross , A , Steyn-Ross , M , Pudney , C R , Van der Kamp , M W , Schipper , L A ,

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Modulation of Antioxidant Enzyme Expression of In Vitro Culture-Derived Reticulocytes

• Authors : Langlands, Hannah D; Shoemark, Deborah K; Toye, Ash M

• Source: Langlands , H D , Shoemark , D K & Toye , A M 2024 , ' Modulation of Antioxidant Enzyme Expression of In Vitro Culture-Derived Reticulocytes ' , Antioxidants , vol. 13 ,

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