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Large-scale organoid study suggests effects of trisomy 21 on early fetal neurodevelopment are more subtle than variability between isogenic lines and experiments

• Authors : Czerminski, Jan T; King, Oliver D; Lawrence, Jeanne B ...

Subjects: Alzheimer’s disease; Down syndrome; cerebral organoids

• Source: Frontiers in neuroscience ; 16 ; 972201 ; Switzerland

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Modeling Down syndrome neurodevelopment with isogenic cerebral organoids [preprint]

• Authors : Czerminski, Jan T.; King, Oliver D.; Lawrence, Jeanne B. ...

Subjects: Developmental Biology; Down syndrome; cerebral organoids

• Source: bioRxiv

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Consequences of aneuploidy in human fibroblasts with trisomy 21

• Authors : Hwang, Sunyoung; Cavaliere, Paola; Li, Rui ...

Subjects: Down syndrome; aneuploidy; dosage compensation

• Source: Proceedings of the National Academy of Sciences of the United States of America ; 118 ; 6 ; e2014723118

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Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells

• Authors : Hwang, Sunyoung; Williams, Jessica F.; Kneissig, Maja ...

Subjects: Down syndrome; Edwards; Patau

• Source: Cell reports ; 29 ; 8 ; 2473-2488.e5

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Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro

• Authors : Chiang, Jen-Chieh; Jiang, Jun; Newburger, Peter E. ...

Subjects: XIST; Down syndrome; trisomy-silencing

• Source: Nature communications ; 9 ; 1 ; 5180

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Opportunities, barriers, and recommendations in down syndrome research

• Authors : Hendrix, James A.; Lawrence, Jeanne B.;

Subjects: Alzheimer’s disease; Down syndrome; autism spectrum disorder

• Source: Translational science of rare diseases ; 5 ; 3-4 ; 99-129

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Chromosome silencing in vitro reveals trisomy 21 causes cell-autonomous deficits in angiogenesis and early dysregulation in Notch signaling

• Authors : Moon, Jennifer E; Lawrence, Jeanne B; Neurology

Subjects: CP: Developmental biology; Down syndrome; NOTCH signaling

• Source: Cell reports ; 40 ; 6 ; 111174 ; United States

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Translating dosage compensation to trisomy 21

• Authors : Jiang, Jun; Jing, Yuanchun; Cost, Gregory J. ...

Subjects: Down Syndrome; RNA; Long Untranslated

• Source: Nature ; 500 ; 7462 ; 296-300

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Translating dosage compensation to trisomy 21

• Authors : Jiang, Jun; Jing, Yuanchun; Cost, Gregory J.

Subjects: Down syndrome; trisomy 21; chromosome therapy

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