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Academic Journal

Novel Antineoplastic Inducers of Mitochondrial Apoptosis in Human Cancer Cells.

Authors : Kesel AJ; Independent Researcher, Chammünsterstr. 47, D-81827 München, Bavaria, Germany.

Subjects: Neoplasms*/Neoplasms*/Neoplasms*/drug therapy ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology; Humans

Source: Molecules (Basel, Switzerland) [Molecules] 2024 Feb 19; Vol. 29 (4). Date of Electronic Publication: 2024 Feb 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53.

Authors : Liu Z; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, China.; Yang Y

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Neoplasms*; Animals

Source: Molecules (Basel, Switzerland) [Molecules] 2024 Feb 04; Vol. 29 (3). Date of Electronic Publication: 2024 Feb 04.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Nitric Oxide Donor DETA/NO Inhibits the Growth of Endometrial Cancer Cells by Upregulating the Expression of RASSF1 and CDKN1A.

Authors : Waheed S; Department of Obstetrics & Gynecology, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA. .; Cheng RY

Subjects: Cyclin-Dependent Kinase Inhibitor p21/Cyclin-Dependent Kinase Inhibitor p21/Cyclin-Dependent Kinase Inhibitor p21/*genetics ; Endometrial Neoplasms/Endometrial Neoplasms/Endometrial Neoplasms/*genetics ; Gene Expression Regulation/Gene Expression Regulation/Gene Expression Regulation/*drug effects

Source: Molecules (Basel, Switzerland) [Molecules] 2019 Oct 16; Vol. 24 (20). Date of Electronic Publication: 2019 Oct 16.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Nanoformulation of a Novel Pyrano[2,3-c] Pyrazole Heterocyclic Compound AMDPC Exhibits Anti-Cancer Activity via Blocking the Cell Cycle through a P53 -Independent Pathway.

Authors : Sun X; Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. .; Zhang L

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Breast Neoplasms/Breast Neoplasms/Breast Neoplasms/*metabolism ; Cell Cycle/Cell Cycle/Cell Cycle/*drug effects

Source: Molecules (Basel, Switzerland) [Molecules] 2019 Feb 11; Vol. 24 (3). Date of Electronic Publication: 2019 Feb 11.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Induction of G2/M Cell Cycle Arrest via p38/p21 Waf1/Cip1 -Dependent Signaling Pathway Activation by Bavachinin in Non-Small-Cell Lung Cancer Cells.

Authors : Pai JT; Division of Hematology and Oncology, Tao-Yuan General Hospital, Ministry of Health and Welfare, Taoyuan City 33004, Taiwan.; Hsu MW

Subjects: Carcinoma, Non-Small-Cell Lung/Carcinoma, Non-Small-Cell Lung/Carcinoma, Non-Small-Cell Lung/*drug therapy ; Cell Cycle Checkpoints/Cell Cycle Checkpoints/Cell Cycle Checkpoints/*drug effects ; Flavonoids/Flavonoids/Flavonoids/*pharmacology

Source: Molecules (Basel, Switzerland) [Molecules] 2021 Aug 25; Vol. 26 (17). Date of Electronic Publication: 2021 Aug 25.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

A Natural Degradant of Curcumin, Feruloylacetone Inhibits Cell Proliferation via Inducing Cell Cycle Arrest and a Mitochondrial Apoptotic Pathway in HCT116 Colon Cancer Cells.

Authors : Chou YT; Department of Food Science, National Taiwan Ocean University, Keelung 20224, Taiwan.; Koh YC

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Antioxidants/Antioxidants/Antioxidants/*pharmacology ; Cell Cycle Checkpoints/Cell Cycle Checkpoints/Cell Cycle Checkpoints/*drug effects

Source: Molecules (Basel, Switzerland) [Molecules] 2021 Aug 12; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 12.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Cytotoxic Activity of Organotin(IV) Derivatives with Triazolopyrimidine Containing Exocyclic Oxygen Atoms.

Authors : Attanzio A; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Parco d'Orleans II, Viale delle Scienze-Pad., 16-90128 Palermo, Italy.; D'Agostino S

Subjects: Gene Expression Regulation, Neoplastic*; Apoptosis/Apoptosis/Apoptosis/*drug effects ; Cytotoxins/Cytotoxins/Cytotoxins/*pharmacology

Source: Molecules (Basel, Switzerland) [Molecules] 2020 Feb 15; Vol. 25 (4). Date of Electronic Publication: 2020 Feb 15.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Tamoxifen and the PI3K Inhibitor: LY294002 Synergistically Induce Apoptosis and Cell Cycle Arrest in Breast Cancer MCF-7 Cells.

Authors : Abdallah ME; Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.; El-Readi MZ

Subjects: Breast Neoplasms/Breast Neoplasms/Breast Neoplasms/*metabolism ; Cell Cycle Checkpoints/Cell Cycle Checkpoints/Cell Cycle Checkpoints/*drug effects ; Chromones/Chromones/Chromones/*pharmacology

Source: Molecules (Basel, Switzerland) [Molecules] 2020 Jul 24; Vol. 25 (15). Date of Electronic Publication: 2020 Jul 24.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Imperatorin as a Promising Chemotherapeutic Agent Against Human Larynx Cancer and Rhabdomyosarcoma Cells.

Authors : Grabarska A; Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.; Skalicka-Woźniak K

Subjects: Antineoplastic Agents, Phytogenic/Antineoplastic Agents, Phytogenic/Antineoplastic Agents, Phytogenic/*pharmacology ; Furocoumarins/Furocoumarins/Furocoumarins/*pharmacology ; Laryngeal Neoplasms/Laryngeal Neoplasms/Laryngeal Neoplasms/*pathology

Source: Molecules (Basel, Switzerland) [Molecules] 2020 Apr 28; Vol. 25 (9). Date of Electronic Publication: 2020 Apr 28.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

The Antiproliferative Activity of Oxypeucedanin via Induction of G 2 /M Phase Cell Cycle Arrest and p53-Dependent MDM2/p21 Expression in Human Hepatoma Cells.

Authors : Park SH; College of Pharmacy, Natural Products Research Institute, Seoul National University, 08826 Seoul, Korea.; Hong JY

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/*drug therapy ; Furocoumarins/Furocoumarins/Furocoumarins/*pharmacology

Source: Molecules (Basel, Switzerland) [Molecules] 2020 Jan 23; Vol. 25 (3). Date of Electronic Publication: 2020 Jan 23.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Novel Antineoplastic Inducers of Mitochondrial Apoptosis in Human Cancer Cells.

Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53.

Nitric Oxide Donor DETA/NO Inhibits the Growth of Endometrial Cancer Cells by Upregulating the Expression of RASSF1 and CDKN1A.

Nanoformulation of a Novel Pyrano[2,3-c] Pyrazole Heterocyclic Compound AMDPC Exhibits Anti-Cancer Activity via Blocking the Cell Cycle through a P53 -Independent Pathway.

Induction of G2/M Cell Cycle Arrest via p38/p21 Waf1/Cip1 -Dependent Signaling Pathway Activation by Bavachinin in Non-Small-Cell Lung Cancer Cells.

A Natural Degradant of Curcumin, Feruloylacetone Inhibits Cell Proliferation via Inducing Cell Cycle Arrest and a Mitochondrial Apoptotic Pathway in HCT116 Colon Cancer Cells.

Cytotoxic Activity of Organotin(IV) Derivatives with Triazolopyrimidine Containing Exocyclic Oxygen Atoms.

Tamoxifen and the PI3K Inhibitor: LY294002 Synergistically Induce Apoptosis and Cell Cycle Arrest in Breast Cancer MCF-7 Cells.

Imperatorin as a Promising Chemotherapeutic Agent Against Human Larynx Cancer and Rhabdomyosarcoma Cells.

The Antiproliferative Activity of Oxypeucedanin via Induction of G 2 /M Phase Cell Cycle Arrest and p53-Dependent MDM2/p21 Expression in Human Hepatoma Cells.