Search Results

Discovery research in physiologically maintained deceased.

• Authors : Pet DB; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.; Department of Neurology, Zuckerberg San Francisco General Hospital, University of California, San Francisco, CA, USA.

Subjects: Biomedical Research*/Biomedical Research*/Biomedical Research*/ethics ; Death* ; Organ Preservation*/Organ Preservation*/Organ Preservation*/ethics

• Source: Science (New York, N.Y.) [Science] 2025 May; Vol. 388 (6746), pp. 473-476. Date of Electronic Publication: 2025 May 01.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

Record details

Modeling of Blood-Brain Barrier (BBB) Dysfunction and Immune Cell Migration Using Human BBB-on-a-Chip for Drug Discovery Research.

• Authors : Ohbuchi M; Applied Research & Operations, Astellas Pharma Inc., Tsukuba 305-8585, Ibaraki, Japan.; Shibuta M

Subjects: Blood-Brain Barrier*/Blood-Brain Barrier*/Blood-Brain Barrier*/metabolism ; Blood-Brain Barrier*/Blood-Brain Barrier*/Blood-Brain Barrier*/drug effects ; Cell Movement*/Cell Movement*/Cell Movement*/drug effects

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 12; Vol. 25 (12). Date of Electronic Publication: 2024 Jun 12.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

Record details

The prospects of automation in drug discovery research using silkworms.

• Authors : Miyashita A; Teikyo University Institute of Medical Mycology, Tokyo, Japan.; Miyauchi M

Subjects: Automation, Laboratory* ; Bombyx* ; Drug Discovery*/Drug Discovery*/Drug Discovery*/methods

• Source: Drug discoveries & therapeutics [Drug Discov Ther] 2024 Jun 06; Vol. 18 (2), pp. 130-133. Date of Electronic Publication: 2024 Apr 04.Publisher: Shandong University China-Japan Cooperation Center for Drug Discovery & Screen Country of Publication: Japan NLM ID:

Record details

Advancing clinical practice and discovery research through revised taxonomy: Case in point bipolar disorder diagnosis: Commentary on "The diagnosis of bipolar disorder in children and adolescents: Past, present and future".

• Authors : Duffy A; Department of Psychiatry, Queen's University, Kingston, Ontario, Canada.; Department of Psychiatry, University of Oxford, Oxford, UK.

Subjects: Bipolar Disorder*/Bipolar Disorder*/Bipolar Disorder*/diagnosis ; Bipolar Disorder*/Bipolar Disorder*/Bipolar Disorder*/classification; Humans

• Source: Bipolar disorders [Bipolar Disord] 2024 May; Vol. 26 (3), pp. 286-288. Date of Electronic Publication: 2024 Mar 07.Publisher: Wiley-Blackwell Munksgaard Country of Publication: Denmark NLM ID: 100883596 Publication Model: Print-Electronic Cited Medium: Internet

Record details

Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery research.

• Authors : Inui T; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Laboratory of Functional Organoid for Drug Discovery, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, 567-0085, Japan.

Subjects: Induced Pluripotent Stem Cells*/Induced Pluripotent Stem Cells*/Induced Pluripotent Stem Cells*/metabolism; Humans ; ATP Binding Cassette Transporter, Subfamily G, Member 2/ATP Binding Cassette Transporter, Subfamily G, Member 2/ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism

• Source: Stem cell research & therapy [Stem Cell Res Ther] 2024 Feb 29; Vol. 15 (1), pp. 57. Date of Electronic Publication: 2024 Feb 29.Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512

Record details

Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research.

• Authors : Sun H; Biologic Therapeutic Discovery, Amgen Research, South San Francisco, California, United States of America.; Wang S

Subjects: Kidney*/Kidney*/Kidney*/metabolism; Cricetinae ; Animals

• Source: PloS one [PLoS One] 2023 Jun 02; Vol. 18 (6), pp. e0285971. Date of Electronic Publication: 2023 Jun 02 (Print Publication: 2023).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

Record details

Drug discovery research in Ghana, challenges, current efforts, and the way forward.

• Authors : Amewu RK; Department of Chemistry, University of Ghana, Legon-Accra, Ghana.; Amoateng P

Subjects: Drug Discovery*; Ghana ; Humans

• Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2022 Sep 15; Vol. 16 (9), pp. e0010645. Date of Electronic Publication: 2022 Sep 15 (Print Publication: 2022).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet

Record details

Tetanus Toxin Fragment C: Structure, Drug Discovery Research and Production.

• Authors : Bayart C; Analytical Sciences, Sanofi, 31/33 Quai Armand Barbès, 69250 Neuville-sur-Saône, France.; Mularoni A

• Source: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 Jun 17; Vol. 15 (6). Date of Electronic Publication: 2022 Jun 17.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print)

Record details

Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System.

• Authors : Negoro R; Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu 525-8577, Japan.; Tasaka M

Subjects: Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/metabolism ; Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/genetics ; Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/metabolism

• Source: Cells [Cells] 2022 May 18; Vol. 11 (10). Date of Electronic Publication: 2022 May 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

Record details

Discovery research and development history of the dopamine D 2 receptor partial agonists, aripiprazole and brexpiprazole.

• Authors : Kikuchi T; New Drug Research Division, Pharmaceutical Business Division, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.; Maeda K

Subjects: Depressive Disorder, Major*/Depressive Disorder, Major*/Depressive Disorder, Major*/drug therapy ; Dopamine Agonists*/Dopamine Agonists*/Dopamine Agonists*/therapeutic use; Aripiprazole/Aripiprazole/Aripiprazole/therapeutic use

• Source: Neuropsychopharmacology reports [Neuropsychopharmacol Rep] 2021 Jun; Vol. 41 (2), pp. 134-143. Date of Electronic Publication: 2021 May 07.Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101719700 Publication Model: Print-Electronic Cited Medium: Internet

Record details