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Academic Journal

De novo design of drug-binding proteins with predictable binding energy and specificity.

Authors : Lei Lu; Xuxu Gou; Tan, Sophia K.

Subjects: BINDING energy; PROTEIN binding; CARRIER proteins

Source: Science. 4/5/2024, Vol. 384 Issue 6691, p106-112. 7p. 5 Diagrams.

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Academic Journal

Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS.

Authors : Schulze, Christopher J.; Seamon, Kyle J.; Yulei Zhao

Subjects: RAS oncogenes; SMALL molecules; CARRIER proteins

Source: Science. 8/18/2023, Vol. 381 Issue 6659, p794-799. 6p. 4 Diagrams.

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Academic Journal

Scaffolding protein functional sites using deep learning.

Authors : Wang, Jue; Lisanza, Sidney; Juergens, David

Subjects: PROTEIN binding; PROTEIN structure; IMMUNOGENETICS

Source: Science. 7/22/2022, Vol. 377 Issue 6604, p387-394. 8p. 5 Diagrams.

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Academic Journal

Sequence specificity in DNA binding is mainly governed by association.

Authors : Marklund, Emil; Mao, Guanzhong; Yuan, Jinwen

Subjects: PROTEIN binding; DNA-binding proteins; CARRIER proteins

Source: Science. 1/28/2022, Vol. 375 Issue 6579, p442-445. 4p. 4 Diagrams.

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Academic Journal

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants.

Authors : Yuan, Meng; Huang, Deli; Lee, Chang-Chun D.

Subjects: BINDING site assay; ANALYTICAL biochemistry; LIGAND binding

Source: Science. 8/13/2021, Vol. 373 Issue 6556, p818-823. 6p. 3 Diagrams, 1 Graph.

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Academic Journal

Pervasive functional translation of noncanonical human open reading frames.

Authors : Chen, Jin; Brunner, Andreas-David; Cogan, J. Zachery

Subjects: OPEN reading frames (Genetics); RIBOSOMES; CRISPRS

Source: Science. 3/6/2020, Vol. 367 Issue 6482, p1140-1146. 7p. 4 Diagrams.

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Academic Journal

Protein decoys may battle COVID-19 and more.

Authors : Service, Robert F.

Subjects: ANGIOTENSIN converting enzyme; PROTEIN binding; COVID-19 pandemic

Source: Science. 2/3/2023, Vol. 379 Issue 6631, p427-428. 2p. 1 Color Photograph.

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Academic Journal

Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions.

Authors : Hochberg, Georg K. A.; Shepherd, Dale A.; Marklund, Erik G.

Subjects: HEAT shock proteins; PROTEIN binding; PROTEIN structure

Source: Science. 2/23/2018, Vol. 359 Issue 6378, p930-935. 6p. 1 Color Photograph, 1 Diagram, 2 Graphs.

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Academic Journal

Stable recombination hotspots in birds.

Authors : Singhal, Sonal; Leffler, Ellen M.; Sannareddy, Keerthi

Subjects: BIRDS; GENETICS; RECOMBINATION hotspots

Source: Science. 11/20/2015, Vol. 350 Issue 6263, p928-932. 5p.

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Academic Journal

Arrested replication forks guide retrotransposon integration.

Authors : Jacobs, Jake Z.; Rosado-Lugo, Jesus D.; Cranz-Mileva, Susanne

Subjects: RETROTRANSPOSONS; GENOMES; GENOMICS

Source: Science. 9/25/2015, Vol. 349 Issue 6255, p1549-1553. 5p.

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