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Academic Journal

Assessing and mitigating pH-mediated DDI risks in drug development – formulation approaches and clinical considerations.

Authors : Wu, Di¹ (AUTHOR) ; Liu, Jiaying¹ (AUTHOR); Paragas, Erickson M.² (AUTHOR)

Source: Drug Metabolism Reviews. Aug2025, Vol. 57 Issue 3, p291-310. 20p.

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Academic Journal

Enzyme-mediated drug-drug interactions: a review of in vivo and in vitro methodologies, regulatory guidance, and translation to the clinic.

Authors : Yadav, Jaydeep¹ (AUTHOR); Maldonato, Benjamin J.² (AUTHOR) ; Roesner, Joseph M.¹ (AUTHOR)

Source: Drug Metabolism Reviews. Aug2025, Vol. 57 Issue 3, p211-243. 33p.

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Academic Journal

Mechanism-based inactivation of cytochrome P450 enzymes by natural products based on metabolic activation.

Authors : Zhang, Tingting^1,2 (AUTHOR); Rao, Jinqiu^1,2 (AUTHOR); Li, Wei^1,3 (AUTHOR)

Source: Drug Metabolism Reviews. Nov2020, Vol. 52 Issue 4, p501-530. 30p.

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Academic Journal

Transporter-mediated drug-drug interactions: regulatory guidelines, in vitro and in vivo methodologies and translation, special populations, and the blood-brain barrier.

Authors : Russell, Laura E.¹ (AUTHOR) ; Yadav, Jaydeep² (AUTHOR); Maldonato, Benjamin J.³ (AUTHOR)

Source: Drug Metabolism Reviews. Aug2025, Vol. 57 Issue 3, p244-271. 28p.

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Academic Journal

Novel insights in drug transporter sciences: the year 2021 in review.

Authors : Chothe, Paresh P.¹ (AUTHOR); Mitra, Pallabi² (AUTHOR); Nakakariya, Masanori³ (AUTHOR)

Source: Drug Metabolism Reviews. Aug2022, Vol. 54 Issue 3, p299-317. 19p.

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Academic Journal

Novel pre-clinical methodologies for pharmacokinetic drug-drug interaction studies: spotlight on 'humanized' animal models.

Authors : Jaiswal, Swati^1,2 (AUTHOR); Sharma, Abhisheak^1,2 (AUTHOR); Shukla, Mahendra^1,2 (AUTHOR)

Source: Drug Metabolism Reviews. Nov2014, Vol. 46 Issue 4, p475-493. 19p.

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Academic Journal

Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development.

Authors : Sinz, Michael W.¹ (AUTHOR)

Source: Drug Metabolism Reviews. Feb2013, Vol. 45 Issue 1, p3-14. 12p.

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Assessing and mitigating pH-mediated DDI risks in drug development – formulation approaches and clinical considerations.

Enzyme-mediated drug-drug interactions: a review of in vivo and in vitro methodologies, regulatory guidance, and translation to the clinic.

Mechanism-based inactivation of cytochrome P450 enzymes by natural products based on metabolic activation.

Transporter-mediated drug-drug interactions: regulatory guidelines, in vitro and in vivo methodologies and translation, special populations, and the blood-brain barrier.

Novel insights in drug transporter sciences: the year 2021 in review.

Novel pre-clinical methodologies for pharmacokinetic drug-drug interaction studies: spotlight on 'humanized' animal models.

Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development.

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