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Academic Journal

Genome-wide DNA hypermethylation opposes healing in patients with chronic wounds by impairing epithelial-mesenchymal transition.

Authors : Singh, Kanhaiya^1,2 ; Rustagi, Yashika¹; Abouhashem, Ahmed S.^1,3

Subjects: *DNA; *ANIMAL experimentation; *DNA methylation

Source: Journal of Clinical Investigation. 9/1/2022, Vol. 132 Issue 17, p1-16. 16p.

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Academic Journal

Hematopoietic transcription factor GFI1 promotes anchorage independence by sustaining ERK activity in cancer cells.

Authors : Hao Wang¹; Zhenzhen Lin¹; Zhe Nian¹

Subjects: *PROTEINS; *LUNG tumors; *DNA-binding proteins

Source: Journal of Clinical Investigation. 9/1/2022, Vol. 132 Issue 17, p1-15. 15p.

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Academic Journal

Genomic and transcriptomic profiling reveals distinct molecular subsets associated with outcomes in mantle cell lymphoma.

Authors : Shuhua Yi^1,2; Yuting Yan^1,2; Meiling Jin

Subjects: *MANTLE cell lymphoma; *B cell receptors; *TRANSCRIPTOMES

Source: Journal of Clinical Investigation. Feb2022, Vol. 132 Issue 3, p1-18. 18p.

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Academic Journal

Epigenetics in glaucoma: a link between DNA methylation and neurodegeneration.

Authors : Liu, Wendy W.¹ ; Yang Sun^1,2 ; Sun, Yang^3,4

Subjects: *GLAUCOMA; *RESEARCH funding; *INTRAOCULAR pressure

Source: Journal of Clinical Investigation. 11/1/2022, Vol. 132 Issue 21, p1-3. 3p.

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Academic Journal

DNA methylome and transcriptome landscapes of cancer-associated fibroblasts reveal a smoking-associated malignancy index.

Authors : Sheng-Fang Su^1,2,3; Hao Ho¹; Jia-Hua Li¹

Subjects: *FIBROBLASTS; *DNA methylation; *DISEASE relapse

Source: Journal of Clinical Investigation. 8/16/2021, Vol. 131 Issue 16, p1-12. 12p.

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Academic Journal

Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B cell acute lymphoblastic leukemia.

Authors : Tejedor, Juan Ramón^1,2,3,4,5,6; Bueno, Clara^7,8,9; Vinyoles, Meritxell^7,8

Subjects: *LYMPHOBLASTIC leukemia; *CANCER cell analysis; *ACUTE leukemia

Source: Journal of Clinical Investigation. 7/1/2021, Vol. 131 Issue 13, p1-19. 19p.

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Academic Journal

Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation.

Authors : Simonett, Shane P.¹; Shin, Sunyoung²; Herring, Jacob A.³

Subjects: *PROTEIN metabolism; *PROTEINS; *RESEARCH

Source: Journal of Clinical Investigation. 11/1/2021, Vol. 131 Issue 21, p1-13. 13p.

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Academic Journal

TET repression and increased DNMT activity synergistically induce aberrant DNA methylation.

Authors : Takeshima, Hideyuki¹ (AUTHOR); Niwa, Tohru¹ (AUTHOR); Yamashita, Satoshi¹ (AUTHOR)

Subjects: *RNA metabolism; *DNA metabolism; *ANIMAL experimentation

Source: Journal of Clinical Investigation. Oct2020, Vol. 130 Issue 10, p5370-5379. 10p.

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Academic Journal

Impaired complex I repair causes recessive Leber's hereditary optic neuropathy.

Authors : Stenton, Sarah L.^1,2; Sheremet, Natalia L.³; Catarino, Claudia B.⁴

Subjects: *MITOCHONDRIAL DNA; *MOLECULAR chaperones; *REACTIVE oxygen species

Source: Journal of Clinical Investigation. 3/15/2021, Vol. 131 Issue 6, p1-12. 12p.

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Academic Journal

RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.

Authors : Patel, Parasvi S.¹; Abraham, Karan Joshua²; Naidu Guturi, Kiran Kumar¹

Subjects: *UBIQUITIN ligases; *DOUBLE-strand DNA breaks; *GENES

Source: Journal of Clinical Investigation. 2/1/2021, Vol. 131 Issue 3, p1-14. 14p.

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