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Gnb5 is a negative regulator of the BACE1-mediated Aβ generation and ameliorates cognitive deficits in a mouse model of Alzheimer's disease.

• Authors : Chen, Shaokun¹ (AUTHOR); Zhou, Jiechao¹ (AUTHOR); Wang, Shuzhong¹ (AUTHOR)

• Source: PLoS Biology. 6/30/2025, Vol. 23 Issue 6, p1-21. 21p.

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Monocyte-secreted Wnt reduces the efficiency of central nervous system remyelination.

• Authors : Hill BM; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, Ontario, Canada.; BARLO Multiple Sclerosis Centre, St. Michael's Hospital, Toronto, Ontario, Canada.

Subjects: Monocytes*/Monocytes*/Monocytes*/metabolism ; Remyelination*/Remyelination*/Remyelination*/physiology ; Central Nervous System*/Central Nervous System*/Central Nervous System*/metabolism

• Source: PLoS biology [PLoS Biol] 2025 Apr 15; Vol. 23 (4), pp. e3003073. Date of Electronic Publication: 2025 Apr 15 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet

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Mdga2 deficiency leads to an aberrant activation of BDNF/TrkB signaling that underlies autism-relevant synaptic and behavioral changes in mice.

• Authors : Zhao D; Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.; Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China.

Subjects: Brain-Derived Neurotrophic Factor*/Brain-Derived Neurotrophic Factor*/Brain-Derived Neurotrophic Factor*/metabolism ; Receptor, trkB*/Receptor, trkB*/Receptor, trkB*/metabolism ; Membrane Glycoproteins*/Membrane Glycoproteins*/Membrane Glycoproteins*/metabolism

• Source: PLoS biology [PLoS Biol] 2025 Apr 01; Vol. 23 (4), pp. e3003047. Date of Electronic Publication: 2025 Apr 01 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet

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Innovations in noninvasive sensory stimulation treatments to combat Alzheimer's disease.

• Authors : Park JM; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/therapy ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/physiopathology; Humans

• Source: PLoS biology [PLoS Biol] 2025 Feb 28; Vol. 23 (2), pp. e3003046. Date of Electronic Publication: 2025 Feb 28 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet

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The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkinson's disease.

• Authors : Dai L; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.; Wang J

Subjects: alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; Parkinson Disease*/Parkinson Disease*/Parkinson Disease*/pathology ; Parkinson Disease*/Parkinson Disease*/Parkinson Disease*/metabolism

• Source: PLoS biology [PLoS Biol] 2025 Feb 18; Vol. 23 (2), pp. e3002974. Date of Electronic Publication: 2025 Feb 18 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet

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Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain.

• Authors : Singh DND; Brain Plasticity & Regeneration Lab, Birmingham Centre for Neurogenetics, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.; Institute of Immunity and Infection, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.

Subjects: Drosophila Proteins*/Drosophila Proteins*/Drosophila Proteins*/metabolism ; Drosophila Proteins*/Drosophila Proteins*/Drosophila Proteins*/genetics ; Drosophila Proteins*/Drosophila Proteins*/Drosophila Proteins*/immunology

• Source: PLoS biology [PLoS Biol] 2025 Feb 13; Vol. 23 (2), pp. e3003020. Date of Electronic Publication: 2025 Feb 13 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet

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Supraspinal facilitation of painful stimuli by glutamatergic innervation from the retrosplenial to the anterior cingulate cortex.

• Authors : Hao S; Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou, China.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China.

Subjects: Gyrus Cinguli*/Gyrus Cinguli*/Gyrus Cinguli*/physiology ; Gyrus Cinguli*/Gyrus Cinguli*/Gyrus Cinguli*/physiopathology ; Gyrus Cinguli*/Gyrus Cinguli*/Gyrus Cinguli*/metabolism

• Source: PLoS biology [PLoS Biol] 2025 Jan 27; Vol. 23 (1), pp. e3003011. Date of Electronic Publication: 2025 Jan 27 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet

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Are oligodendrocytes bystanders or drivers of Parkinson's disease pathology?

• Authors : Salazar Campos JM; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Munich, Germany.; Burbulla LF

Subjects: Oligodendroglia*/Oligodendroglia*/Oligodendroglia*/metabolism ; Oligodendroglia*/Oligodendroglia*/Oligodendroglia*/pathology ; Parkinson Disease*/Parkinson Disease*/Parkinson Disease*/pathology

• Source: PLoS biology [PLoS Biol] 2025 Jan 08; Vol. 23 (1), pp. e3002977. Date of Electronic Publication: 2025 Jan 08 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet

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Amyloid accelerator polyphosphate fits as the mystery density in α-synuclein fibrils.

• Authors : Huettemann P; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America.; Mahadevan P

Subjects: Polyphosphates*/Polyphosphates*/Polyphosphates*/metabolism ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/chemistry

• Source: PLoS biology [PLoS Biol] 2024 Oct 31; Vol. 22 (10), pp. e3002650. Date of Electronic Publication: 2024 Oct 31 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet

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Remember oligodendrocytes: Uncovering their overlooked role in Alzheimer's disease.

• Authors : Spieth L; Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/pathology ; Oligodendroglia*/Oligodendroglia*/Oligodendroglia*/metabolism

• Source: PLoS biology [PLoS Biol] 2024 Sep 12; Vol. 22 (9), pp. e3002798. Date of Electronic Publication: 2024 Sep 12 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet

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