Search Results

Genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways.

• Authors : Askarova A; Department of Brain Sciences, Imperial College London, London, United Kingdom.; United Kingdom Dementia Research Institute, Imperial College London, London, United Kingdom.

Subjects: Microglia*/Microglia*/Microglia*/metabolism ; Microglia*/Microglia*/Microglia*/pathology ; Genetic Predisposition to Disease*

• Source: PLoS genetics [PLoS Genet] 2025 Apr 09; Vol. 21 (4), pp. e1011407. Date of Electronic Publication: 2025 Apr 09 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet

Record details

NEMF mutations in mice illustrate how Importin-β specific nuclear transport defects recapitulate neurodegenerative disease hallmarks.

• Authors : Plessis-Belair J; Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York, United States of America.; Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York, United States of America.

Subjects: beta Karyopherins*/beta Karyopherins*/beta Karyopherins*/metabolism ; beta Karyopherins*/beta Karyopherins*/beta Karyopherins*/genetics ; Active Transport, Cell Nucleus*/Active Transport, Cell Nucleus*/Active Transport, Cell Nucleus*/genetics

• Source: PLoS genetics [PLoS Genet] 2024 Sep 23; Vol. 20 (9), pp. e1011411. Date of Electronic Publication: 2024 Sep 23 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet

Record details

An Epigenetic Signature in Peripheral Blood Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy

• Authors : Li, Yun; Chen, Jason A; Sears, Renee L

Subjects: Biological Sciences; Genetics; Alzheimer's Disease

• Source: PLOS Genetics. 10(3)

Record details

TTLL1 and TTLL4 polyglutamylases are required for the neurodegenerative phenotypes in pcd mice.

• Authors : Wu, Hui-Yuan^1,2 (AUTHOR); Rong, Yongqi¹ (AUTHOR); Bansal, Parmil K.¹ (AUTHOR)

• Source: PLoS Genetics. 4/11/2022, Vol. 18 Issue 4, p1-25. 25p.

Record details

Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes

• Authors : Tianyou Li; Yang Li; Jie Zhang

Subjects: Neurons; Cell Survival; Fluorescent Antibody Technique

• Source: PLoS GenetPLoS Genetics, Vol 17, Iss 3, p e1009415 (2021)

Record details

Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs.

• Authors : Ramdhani, Satesh^1,2,3 (AUTHOR); Navarro, Elisa^1,2,3 (AUTHOR); Udine, Evan^1,2,3 (AUTHOR)

• Source: PLoS Genetics. 2/3/2020, Vol. 16 Issue 2, p1-23. 23p.

Record details

Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes.

• Authors : Xuezhao Liu; Limin Yin; Tianyou Li

Subjects: Genetics; QH426-470

• Source: PLoS Genetics, Vol 17, Iss 3, p e1009415 (2021)

Record details

Retraction: Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes.

• Authors : Xuezhao Liu; Limin Yin; Tianyou Li

Subjects: Genetics; QH426-470

• Source: PLoS Genetics, Vol 17, Iss 8, p e1009746 (2021)

Record details

A missense change in the ATG4D gene links aberrant autophagy to a neurodegenerative vacuolar storage disease.

• Authors : Kyöstilä K; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland; Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland

Subjects: Mutation, Missense*; Autophagy/Autophagy/Autophagy/*genetics ; Cysteine Endopeptidases/Cysteine Endopeptidases/Cysteine Endopeptidases/*genetics

• Source: PLoS genetics [PLoS Genet] 2015 Apr 15; Vol. 11 (4), pp. e1005169. Date of Electronic Publication: 2015 Apr 15 (Print Publication: 2015).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet

Record details

Altered energy metabolism in Fatal Familial Insomnia cerebral organoids is associated with astrogliosis and neuronal dysfunction.

• Authors : Foliaki ST; Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Division of Intramural Research, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana, United States of America.; Smith A

Subjects: Insomnia, Fatal Familial*/Insomnia, Fatal Familial*/Insomnia, Fatal Familial*/genetics ; Insomnia, Fatal Familial*/Insomnia, Fatal Familial*/Insomnia, Fatal Familial*/metabolism ; Neurodegenerative Diseases*/Neurodegenerative Diseases*/Neurodegenerative Diseases*/metabolism

• Source: PLoS genetics [PLoS Genet] 2023 Jan 19; Vol. 19 (1), pp. e1010565. Date of Electronic Publication: 2023 Jan 19 (Print Publication: 2023).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet

Record details